Examguru Hematology Oncology

Question 1

small lymphocytes on peripheral smear that are very fragile

Answer 1

chronic lymphocytic leukemia or small lymphocytic leukemia

Question 2

marked leukocytosis and well differentiated myeloblasts

Answer 2

CML- use tyrosine inhibitors

Question 3

leukoblasts with hairy projections and TRAP positive

Answer 3

Hairy cell leukemia- no tx unless symptomatic

Question 4

more than 20% blasts on bone marrow biopx

Answer 4

AML

Question 5

less than 20% blasts on bone marrow and cytopenia

Answer 5

Myelodysplastic syndrome

Question 6

less than 20% blasts on bone marrow biopx and hyperproliferation of myeloid cells

Answer 6

Myeloproliferative syndrome

Question 7

MPDs =

Answer 7

essential thrombocytopenia, polycythemia vera, myelofibrosis, mastocytosis

Question 8

asymptomatic patient with a depressed myeloid cell line

Answer 8

MDS

Question 9

del5(q)

Answer 9

MDS –> AML

Question 10

IgM spike on electrophoresis

Answer 10

Waldenstrom’s

Question 11

IgG spike on electrophoresis

Answer 11

Multiple Myeloma

Question 12

secondary polycythemia

Answer 12

CO poisoning, sleep apnea, high altitude, steroid abuse, paraneoplastic EPO synthesizing drugs

Question 13

what forms of polycythemia vera have increased EPO?

Answer 13

all of them EXCEPT polycythemia vera

Question 14

decrease in all three hematopoetic cell lines in the presence of an inciting factor

Answer 14

aplastic anemia- fibrosis of marrow

Question 15

“N TIME2”

Answer 15

Neutropenia, Thrombocytopenia, Infections, IgM (decreased), IgE (increased)- Wiskott Aldrich Syndrome