Psychiatry Pharm: Indications, helpful mnemonics Flashcards
Try to Fly High- class of drugs
High Potency typical antipsychotics: block D2 and alpha 1 receptors
have high EPS, less specific symptoms like galactorrhea, amenorrhea
Cheating Thieves are Low- class of drugs
Low Potency typical antipsychotics,
Try to Fly High- Drugs
Trifluoperazine, fluphenazine, haloperidol
Cheating Thieves are Low- Drugs
Chlorpromazine, Thioridazine
Why are cheating thieves low?
because they have less neurological effects and more anticholinergic effects
Why makes high potency anti psychotics high potency?
more neurological effects, more extrapyramidal effects
what are the suffixes for atypical antipsychotics?
-peridone, -idone, -apine
two odd ball atypical antipsychotics
Ariprazole (partial D2 agonist) and clozapine (agranulocytosis)
what makes atypicals different from typical?
varied effects- Dopamine Rs, 5HT2Rs, alpha and histamine receptors.
Indication: ADHD
stimulants
Indication: Alcohol withdrawal
benzodiazepines
Indication: bipolar disorder
lithium and several others
bulimia nervosa
SSRIs
depression
SSRIs
Generalized anxiety disorder
SSRIs, SNRIs
Obsessive-compulsive disorder
SSRIs, venlafaxine, clomipramine
Panic disorder
SSRIs, venlafaxine, benzeodiazapines
PTSD
SSRIs, venlafaxine
Schizophrenia
atypical antipsychotic,
social anxiety disorder
SSRIs, venlafaxine
performative social anxiety disorder drugs
b-blockers, benzodiazepines
chlorpromazine: class, tx, SE
low potency antipsychotic
used for intractable hiccups. SE: corneal/lens pigmentation
thioridazine: : class, tx, SE
low potency antipsychotic, used to treat overdose with bicarb (wolfpacc handout), SE retinal dispigmentation
atypical antipsychotics MOA
block D4, 5HT2. minimal side effects.
blocks reuptake of NE and 5HT
TCAs
blocks 5HT reuptake
SSRIs
blocks D2 receptors
antipyschotics
SIG E CAPS
Major Depressive Disorder
Sleep disturbances, Loss of interest, Guilt of feelings of worthlessness, Energy loss/fatigue, Concentration problems, Appetite/weight changes, Psychomotor retardation or agitation, suicidal ideations
TriC
Tricyclic Antidepressant toxicity: Convulsions, Coma, Cardiotoxicity (arrythmia)
Malignant FEVER
Neuleptic Malignant Syndrome: Myoglobinuria, Fever, Encephlopathy, Vitals unstable, Increased Enzymes (CK goes up), Rigidity of Muscles (“lead pipe”), and hyperthermia
the Three C’s of TriC
Tricyclic Antidepressant toxicity: Convulsions, Coma, Cardiotoxicity (arrythmia)
Weird, Wild and Worried
Weird: Cluster A personality disorders: accusatory, aloof, awkward
Wild: Cluster B personality disorders: Bad, Borderline, flamBoyant, but be the Best
Worried: Cluster C personality disorders: Cowardly, obsessive Compulsive, clingy
PTSD is HARD
Hyperarousal, Avoidance of associated stimuli, Rexperiencing events, DISTRESS/horror/fear (changes in mood)
SAD PERSONS
Suicide RFs Sex (male), Age (young adult/elderly), Depression, Previous attempt, Ethanol/drug abuse, Rational thinking loss (psychosis), Sickness (medical illness), Organized plan, No spouse or other social support, State future intent
DIG FAST
Manic Episode: flight of ideas (racing thoughts), Agitation/increased Activity with specific goal in mind, decreased need for Sleep, Talkativeness or pressured speech
