:Q Flashcards
define:
anterograde degeneration [1]
retrograde degeneration [1]
transneuronal degeneration [1]
- *- anterograde degeneration:** when the axon distal to the site of injury degenerates
- *- retrograde degeneration**: when the proximal segment starts to degenerate)
- transneuronal degeneration: the death of neurons resulting from the disruption of input from or output to other nearby neurons.
what is wallerian degeneration?
Wallerian degeneration is an active process of retrograde degeneration of the distal end of an axon that is a result of a nerve lesion. It occurs between 7 to 21 days after the lesion occurs. After the 21st day, acute nerve degeneration will show on the electromyograph.
what is neurapraxia? [1]
what is axonotmesis?
what is neurotmesis?
which of the following are reversible?
neurapraxia: temporary loss of motor and sensory function due to blockage of nerve conduction (temporary damage to myelin). reversible
axonotmesis: disruption of the axons, resulting from severe crush or contusion. myelin and axon damaged. reversible (epineurium still intact)
neurotmesis: both the axons and nerve sheath are disrupted: 3rd degree damage. myelin and axon AND epineurium damaged. partial recovery possible
after nerve injury:
how does the cell communicate that its injured? [3]
what transformation does cell undergo (in function?) [1]
how does the cell communicate that its injured? [3]
- get a burst of APs (alerts the cell body in DRG that damage has occurred)
- disruption of retrograde transport flow of trophic support (this is a negative injury signal bc its a stop to normal procedure)
- postive injury signals
= all alert DRG that is damaged !!
what transformation does cell undergo (in function?) [1]
cells in the DRG alter their phenotype (switch from transmission of information state to growth state.
how does nerve regeneration occur? which cells are involved
the process of nerve regeneration:
- schwann cells divide & secrete trophic factors to attract axon then remyelinate new axons
spinal cord trauma produces what? occurs from here? [2]
what do macrophages and glial cells make when spinal cord injury occurs? [1]
spinal cord trauma produces what? occurs from here? [2]
site of primary cell death: rapidly spreads into a zone of secondary cell death|
then produces a zone of secondary cell death
(spinal cord injury occurs from both primary and secondary cell death)
macrophages and microglia engulf debri and injury site becomes walled off by a glial scar
what are the two main barriers to CNS repair?
- *1. hostile environment**
i) scar tissue
ii) myelin-associated inhib proteins (NOGO proteins, MAG, OMGP)
2. poor regenerative response (unlike PNS)
spinal cord trauma produces what? occurs from here? [2]
what do macrophages and glial cells make when spinal cord injury occurs? [1]
spinal cord trauma produces what? occurs from here? [2]
site of primary cell death: rapidly spreads into a zone of secondary cell death|
then produces a zone of secondary cell death
(spinal cord injury occurs from both primary and secondary cell death)
macrophages and microglia engulf debri and injury site becomes walled off by a glial scar:
- engulfs debris
- seals lesion site
- repairs the blood-spinal cord barrier
- expresses chemicals that inhibit axon growth
both a physical and chemical barrier for neuroregeneration
vestibulocochlear nerve:
where does the it arise from?
vestibular part [1]
cochlear part: [1]
vestibulocochlear nerve:
where does the it arise from? [2]
vestibular part: pons & medulla
cochlear part: cerebellar peduncle
A: midbrain - identified by the large cerebral peduncles
B: medulla (superior / open)
C: pons - iD by bugle at front
D medulla inferior
Which of the following extrinsic muscles of the tongue is not innervated by the hypoglossal nerve?
Styloglossus
Hyoglossus
Genioglossus
Palatoglossus
Which of the following extrinsic muscles of the tongue is not innervated by the hypoglossal nerve?
Styloglossus
Hyoglossus
Genioglossus
Palatoglossus: VN instead
Which foramen does the hypoglossal nerve travel through in the skull? [1]
Acceptable responses: Hypoglossal, Hypoglossal canal
the ribosomes in neuron cell bodies appear as clumps called what? [1]
nissil bodies
whar are the SL pictured here? [1]
what type of cell? [1]
whar are the white lines pictured here? [1]
schmidt-lanterman clefts
what type of cell? [1]
schwann cell
what is the role of satellite cells? [1]
where do you find? [1]
which type of staining? [1]
what do they look like? [1]
what is the role of satellite cells? [1]
help maintain the envrioment around neuronal body in the ganglion
where do you find? [1]
cells bodies of ganglia
which type of staining? [1]
H&E
what do they look like? [1]
cuboidal cells
which of the following provide physical & metabolic support for the neurons
oligodendrocytes
ependymal
astrocytes
microglial
schwann
which of the following provide physical & metabolic support for the neurons
oligodendrocytes
ependymal
astrocytes
microglial
schwann
which of the following helps to form BBB?
perineurium
endosteum
periosteal
endoneurium
epineurium
which of the following helps to form BBB?
perineurium
endosteum
periosteal
endoneurium
epineurium
what type of imaging is this?
CT
MRI T2
PET
Ultrasound
MRI T1
what type of imaging is this?
CT
MRI T2
PET
Ultrasound
MRI T1
what is A?
oligodendrocytes
ependymal
astrocytes
microglial
schwann
what is A?
oligodendrocytes
ependymal
astrocytes
microglial
schwann
how do you differentiate microglial cells?
elongated nuclei
small
when stained with heavy metals, exhbit short & twisted processes
what is the cellular organisation of the cerebellum?
in the cortex [3]
in the white matter [1]
- outer hypocellular layer
- middle purkinje cell layer
- inner / deep hypercellular granular lyaer
white matter:
- climbing fibres
- mossy fibres
(axons and supoorting cells)
what are the three cellular layers of blood brain barrier? [3]
tigh junctions of the endothelial cells
continous endothelial basal lamina (pericytes)
end foot processes of astrocytes
what is the cellular organisation of the cerebral cortex?
how can you tell which is the pyramidal layer in the cerebral cortex? [1]
where is the pyramidal layer more developed? [2]
how can you tell which is the pyramidal layer in the cerebral cortex? [1]
larger cell bodies
where is the pyramidal layer more developed? [2]
motor & sensory centres
which cell does the pink arrow point to? (and the other dark cells)
satellite
astrocytes
oligodendrocytes
microglial
ependymal
which cell does the pink arrow point to? (and the other dark cells)
satellite
astrocytes
oligodendrocytes
microglial
ependymal
which structures in the brain does CT angiography specifically visualise? [2]
apart from looking at ischaemic stroke, what can CT angiography be used for? [1]
which structures in the brain does CT angiography specifically visualise? [2]
carotid arteries (External & internal)
circle of willis
apart from looking at ischaemic stroke, what can CT angiography be used for? [1]
aneurysms
which type of imaging is this?
CT venogram
PET scan
CT angiography
CT perfusion
MRI
which type of imaging is this?
CT venogram
PET scan
CT angiography
CT perfusion
MRI
what type of imaging is this?
CT
MRI T2
PET
Ultrasound
MRI T1
what type of imaging is this?
CT
MRI T2
PET
Ultrasound
MRI T1
what is the opercular cortex?
how does it differ between L & R ?
what is the opercular cortex?
cortex on the upper and lower ‘lips’ of the lateral fissure
how does it differ between L & R ?
left
what are minature End Plate Potentials cause by? [1]
random release of NT from vesicles sporadically binding with membrane
- where does Ach bind to ACh R (specifics !!)
- describe structure of Ach R
what happens when Ach binds to ACHR?
structure: α2βγð subunits; spans across inside of cell, cell membrane and outside of cell (where the binding sites are)
when 2 Ach binds to AchR: change in hydrophobic interactions in alpha helical structure = creates an ion pore
binding occurs of Ach occurs at C loops (of cysteine-cysteine bond)
