HYPOTHALAMUS & PITUITARY GLAND Flashcards

1
Q

which of the following lies either side of the thalamus?

  • third ventricle
  • fourth ventricle
  • midbrain
  • corpus callosum
  • lateral ventricles
A

which of the following lies either side of the thalamus?

  • *- third ventricles**
  • fourth ventricle
  • midbrain
  • corpus callosum
  • lateral ventricles
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2
Q

which structure is outlined in green?

  • third ventricle
  • fourth ventricle
  • thalamus
  • corpus callosum
  • lateral ventricles
A

which structure is outlined in green?

- third ventricle
- fourth ventricle
- thalamus
- corpus callosum
- lateral ventricles

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3
Q

what is A? [1]

A
  • pineal gland
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4
Q

which bone does the pituitary gland sit in ?

  • temporal
  • zygomatic
  • sphenoid
  • frontal
  • vomer
A

which bone does the pituitary gland sit in ?

  • temporal
  • zygomatic
  • *- sphenoid**
  • frontal
  • vomer
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5
Q

label A-C

A

A: thalamus
B: hypothalamus
C: pituitary gland

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6
Q

which of the following is the hypothalamus?

A
B
C
D
E

A

which of the following is the hypothalamus?

A
B
C
D
​E

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7
Q

which of the following is the lateral ventricle?

A
B
C
D
​E

A

which of the following is the lateral ventricle?

A
B
C
D
​E

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8
Q

which of the following is the third ventricle?

A
B
C
D
​E

A

which of the following is the third ventricle?

A
B
C
D
​E

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9
Q

which of the following is the interventricular foramen?

A
B
C
D
​E

A

which of the following is the interventricular foramen?

A
B
C
D
​E

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10
Q

which nuclei in the hypothalamus do u need to know? [2]

A

which nuclei in the hypothalamus do u need to know? [2]
paraventricular nucleus
supraoptic nucleus

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11
Q

how is the pituitary split up? [2]

what is the name of the structure that the pituitary sits in? [1]

what is the pituitary stalk aka? [1]

A

how is the pituitary split up? [2]
anterior pituitary
posterior pituitary

what is the name of the structure that the pituitary sits in? [1]
sella turcica

what is the pituitary stalk aka? [1]
infundibulum

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12
Q

what is the difference in anterior and posterior pituitary development? [1]
what are the two kinds out outputs to the pituitary from the hypothalamus? [2]

A

what is the difference in anterior and posterior pituitary development? [1]
posterior pit = direct outgrowth of brain (specifically the hypothalamus)
anterior pit = indirect growth: develops from ectoderm in roof of mouth & migrates up

what are the two kinds out outputs to the pituitary from the hypothalamus? [2]
posterior pit = direct
anterior pit = indirect via a capillary plexus in the stalk of the anterior pit

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13
Q

which part of the pituitary gland do the supraoptic and paraventricular nuclei project into? [1]

what occurs here? [1]

where do the other hypothalamic nuclei release their peptides? [1]

A

which part of the pituitary gland do the supraoptic and paraventricular nuclei project into? [1]
project into the posterior lobe

what occurs here? [1]
release peptides into the capillaries in the posterior pit

where do the other hypothalamic nuclei release their peptides? [1]
capillary plexus in the neck of the pit. stalk

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14
Q

technically, how do you classify:

a) anterior pituitary [1]
b) posterior pituitary [1]

A

technically, how do you classify:

a) anterior pituitary: endocrine gland
b) posterior pituitary: part of the brain

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15
Q

what is A?

A

Sella turcica

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16
Q

what is A? [1]

what type of structure is this? [1]

A

cavernous sinuses: venous sinus.

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17
Q

which structure passes through the centre of the cavernous sinuses? [1]

which CNs pass through the lateral walls of the cavernous sinuses? [3]

A

which structure passes through the centre of the cavernous sinuses? [1]
carotid artery

which CNs pass through the lateral walls of the cavernous sinuses? [3]
**CN III, IV & VI and V1 and V2 of V

optic nerve does not though !!**

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18
Q

what does the hypothalamus (& pit) regulate? [4]

A

what does the hypothalamus & pit regulate? [4]

  • *homeostasis of:
  • temp
  • body water
  • sleep & waking cycles
  • reproduction**
19
Q

out of SNS and PNS, which controls

a) erection?
b) ejaculation?

A

out of SNS and PNS, which controls

a) erection: parasympathetic
b) ejaculation: sympathetic

20
Q

how does the hypothalamus regulate body temperature?

  • where do you find thermoreceptors? [2]
  • how do you know if too hot / cold? [1]
A

how does the hypothalamus regulate body temperature?

  • where do you find thermoreceptors? [2]
  • *i) cutaneous thermoreceptors
    ii) anterior nucleus of hypothalamus: blood temp**
  • how do you know if too hot / cold? [1]
  • *= info from these two sources are compared to set point (in anterior nucleus) & heat loss / gain mech is activated**
21
Q

what are heat loss effectors? [3]

what are heat gain effectors? [4]

A

what are heat loss effectors? [3]
secrete sweat from sweat glands;
cutaneous vasodilation - heat loss by convection & conduction
become inactive (muscle activity generates heat, so stop that)

what are heat gain effectors? [4]

  • stop sweat
  • *- erector pili muscles stand up: pilierection: traps layer of heat
  • vasoconstriction
  • shivering. using glucose to create heat (**when shivering stops is cuz youve used up your glucose & become hypothermic)
22
Q

how does the hypothalamus regulate water balance?

  • where do you find osmoreceptors? [1]
  • which hypothalamic nuclei are stimulated to increase water in ur body ? how do they work?
A
  • where do you find osmoreceptors? [1]
  • *subfornical organ (wall of third ventricle): detects osmolarity**
  • subforrnical organ activates cells in the:
  • *i) medial preoptic nucleus**
  • this nucleus connects to the limbic system: regulates concious sense of thirst
  • *ii) paraventricular nucleus & supraoptic nucleus**
  • secrete ADH (makes more aquaporins in CD)
  • oxytocin
23
Q

what are three mechanisms of ADH reducing water loss? [3]

A
  • Increase aquaporins in CD
  • increases perm. of CD to urea (water follows)
  • stimulates sodium reab in thick loop of henle: Na/K/2Cl
24
Q

how is baby sucking on a breast an example of creating a neuro-hormonal reflex? [2]

how does oxytocin promote maternal bonding? [2]

A

baby sucking on a teat:

  • sucking action is transmitted to the hypothalamus via spinothalamic tract (neuro)
  • releases oyxtocin from posterior pit. (hormonal)
  • activates the milk down reflex

how does oxytocin promote maternal bonding? [2]

  • *- suckiling - causes oxytocin release in mothers brain
  • this is associated with reward - limbic system**
25
Q

* why are ADH and oxytocin in posterior pituitary? * [1]

A

* why are ADH and oxytocin in posterior pituitary? * [1]
needed in fast response to stimulus (adh also release when haemorrhaging)

26
Q

how are anterior pit hormones released? [3]

A

hypothalamic neurosecretory cells release releasing hormones into capillaries

releasing hormones pass down shortal portal vein to anterior pituitary capillaries

this causes the stimulation of hormones from anterior pit cells

27
Q

describe the mechanism of HPA axis (hypothalamus-pit-adrenal axis)

A

describe the mechanism of HPA axis (hypothalamus-pit-adrenal axis):

  • Cells in hypothalamus release CRH (Corticotropin releasing hormone)
  • CRH acts on anterior pit to releease ACTH (adrenocorticotropic hormone)
  • ACTH acts on adrenal cortex to release cortisol
  • *BUT: negative feedback system:**
  • cortisol inhbits release of above
28
Q

why are anterior pituitary hormones released in ‘two hormone’ mechanism?

A

why are anterior pituitary hormones released in ‘two hormone’ mechanism?

**- double negative feedback means hormones are released in cyclic fashion (diurnal system or montly cycles)

WORK IN CYCLES !!**

29
Q
A
30
Q

MESS:

  • how do supraoptic and paraventricular nuclei release peptides in circulation? [1]
  • how does hypothalamic cell bodies from anterior lobe release peptides into circulation? [1]
A

Posterior lobe: Hypothalamic cell bodies in the supraoptic and paraventricular nuclei have axons that project down the pituitary stalk to the posterior lobe of the pituitary. They release peptides into the capillaries in the posterior pituitary which circulate in the blood to other organs

•Anterior lobe: Hypothalamic cell bodies have shorter axons that release peptides on to the capillary plexus in the neck of the pituitary stalk

31
Q

MESS:

how does oxyotcin occur in milk-let down? & what type of reflex

A

•neuro-hormonal reflex.

•Suckling: causes oxytocin to be released into mother’s brain via collateral branches of the oxytocin axons. Project to regions of brain associated with REWARD. It is believed to promote maternal behavioural and bonding with the baby and prevents post-natal depression.

32
Q

MESS

what are the 6 hormones released from AP?

which hypothalamic releasing hormones control the inhibition / release of ^?

A

•Adrenocorticotrophic hormone (ACTH) is released by Corticotrophin Releasing Hormone (CRH)

  • Prolactin (PL) is inhibited by prolactin inhibiting factor (PIF i.e. dopamine).
  • Lutenising hormone (LH) is released by gonadotrophin releasing hormone (GnRH)

•Follicle stimulating hormone (FSH) same as LH so GNRH.

•Thyroid stimulating hormone (TSH) is released by thyroid releasing hormone (TSH)

  • *•Growth hormone (GH**) is released by growth hormone releasing hormone
  • ​Is inhibited by growth hormone inhibiting hormone = somatostatin.
33
Q

which anterior pituitary hormone is inhibited by its hypothalamic releasing hormone?

Adrenocorticotrophic hormone (ACTH)
Prolactin (PL)
Lutenising hormone (LH)
Follicle stimulating hormone (FSH)
Thyroid stimulating hormone (TSH)

A

which anterior pituitary hormone is inhibited by its hypothalamic releasing hormone?

Adrenocorticotrophic hormone (ACTH)
Prolactin (PL): inhibited by prolactin inhbiting factor (e.g. dopamine)
Lutenising hormone (LH)
Follicle stimulating hormone (FSH)
​Thyroid stimulating hormone (TSH)

34
Q

what is growth hormone (GH) inhibited by? [1]

A

•Is inhibited by growth hormone inhibiting hormone = somatostatin.

35
Q

which of the following stimulates production of sex hormones by gonads?

Adrenocorticotrophic hormone (ACTH)
Prolactin (PL)
Lutenising hormone (LH)
Follicle stimulating hormone (FSH)
Thyroid stimulating hormone (TSH)

A

which of the following stimulates production of sex hormones by gonads?

Adrenocorticotrophic hormone (ACTH)
Prolactin (PL)
Lutenising hormone (LH)
Follicle stimulating hormone (FSH)
Thyroid stimulating hormone (TSH)

36
Q

which of the following stimulates production of spem and eggs

Adrenocorticotrophic hormone (ACTH)
Prolactin (PL)
Lutenising hormone (LH)
Follicle stimulating hormone (FSH)
Thyroid stimulating hormone (TSH)

A

which of the following stimulates production of spem and eggs

Adrenocorticotrophic hormone (ACTH)
Prolactin (PL)
Lutenising hormone (LH)
Follicle stimulating hormone (FSH)
Thyroid stimulating hormone (TSH)

37
Q

which of the following regulates metabolism

Adrenocorticotrophic hormone (ACTH)
Prolactin (PL)
Lutenising hormone (LH)
Follicle stimulating hormone (FSH)
Thyroid stimulating hormone (TSH)

A

which of the following regulates metabolism

Adrenocorticotrophic hormone (ACTH)
Prolactin (PL)
Lutenising hormone (LH)
Follicle stimulating hormone (FSH)
Thyroid stimulating hormone (TSH)

38
Q

which of the following induces targers to produce insulin-like growth factors?

Adrenocorticotrophic hormone (ACTH)
Prolactin (PL)
Lutenising hormone (LH)
Follicle stimulating hormone (FSH)
Thyroid stimulating hormone (TSH)
Growth hormone (GH)

A

which of the following induces targers to produce insulin-like growth factors?

Adrenocorticotrophic hormone (ACTH)
Prolactin (PL)
Lutenising hormone (LH)
Follicle stimulating hormone (FSH)
Thyroid stimulating hormone (TSH)
Growth hormone (GH)

39
Q

which of the following regulates metabolism and the stress response?

Adrenocorticotrophic hormone (ACTH)
Prolactin (PL)
Lutenising hormone (LH)
Follicle stimulating hormone (FSH)
Thyroid stimulating hormone (TSH)
Growth hormone (GH)

A

which of the following regulates metabolism and the stress response?

Adrenocorticotrophic hormone (ACTH): releases cortisol
Prolactin (PL)
Lutenising hormone (LH)
Follicle stimulating hormone (FSH)
Thyroid stimulating hormone (TSH)
Growth hormone (GH)

40
Q

which of the following is released by gonadotrophin releasing hormone (GnRH)

Adrenocorticotrophic hormone (ACTH)
Prolactin (PL)
Lutenising hormone (LH)
Follicle stimulating hormone (FSH)
Thyroid stimulating hormone (TSH)
Growth hormone (GH)

A

which of the following is released by gonadotrophin releasing hormone (GnRH)

Adrenocorticotrophic hormone (ACTH)
Prolactin (PL)
Lutenising hormone (LH)
Follicle stimulating hormone (FSH)
Thyroid stimulating hormone (TSH)
Growth hormone (GH)

41
Q

which of the following is inhibited by prolactin inhbiting factor?

Adrenocorticotrophic hormone (ACTH)
Prolactin (PL)
Lutenising hormone (LH)
Follicle stimulating hormone (FSH)
Thyroid stimulating hormone (TSH)
Growth hormone (GH)

A

which of the following is inhibited by prolactin inhbiting factor?

Adrenocorticotrophic hormone (ACTH)
Prolactin (PL)
Lutenising hormone (LH)
Follicle stimulating hormone (FSH)
Thyroid stimulating hormone (TSH)
Growth hormone (GH)

42
Q

which of the following is released by Corticotrophin Releasing Hormone (CRH)

Adrenocorticotrophic hormone (ACTH)
Prolactin (PL)
Lutenising hormone (LH)
Follicle stimulating hormone (FSH)
Thyroid stimulating hormone (TSH)
Growth hormone (GH)

A

which of the following is released by Corticotrophin Releasing Hormone (CRH)

Adrenocorticotrophic hormone (ACTH)
Prolactin (PL)
Lutenising hormone (LH)
Follicle stimulating hormone (FSH)
Thyroid stimulating hormone (TSH)
Growth hormone (GH)

43
Q

which of the following is released gonadotrophin releasing hormone (GnRH) [2]

Adrenocorticotrophic hormone (ACTH)
Prolactin (PL)
Lutenising hormone (LH)
Follicle stimulating hormone (FSH)
Thyroid stimulating hormone (TSH)
Growth hormone (GH)

A

which of the following is released gonadotrophin releasing hormone (GnRH) [2]

Adrenocorticotrophic hormone (ACTH)
Prolactin (PL)
Lutenising hormone (LH)
Follicle stimulating hormone (FSH)

Thyroid stimulating hormone (TSH)
Growth hormone (GH)