Prostaglandin Of Clinical Use Flashcards
The precursors of all prostaglandin is ……….
Arachidonic acid
The prostaglandins which forms precursors for the other prostaglandin are
PGG and PGH
The prostaglandins that are not found in vivo are
PGA and PGB
Phospholipase A2 inhibitor is ……….
Glucocorticoid
How does misopristol induce uterine ripening
By inducing Collagen breakdown
Altering the glycosaminoglycan/ proteoglycan composition
The prostaglandin receptors found in the uterus are
EP 1-4 & IP
What prostaglandin recrptpr mediates PGE2 induced uterine contractility
EP3
What drug can misoprostol be combined with
Mifepristone
Other uses of misopristol include
Primary postpartum hemorrhage
Epoprostenol is an analog of ……. prostaglandins
IP2
Route of administration of misopristol include
Orally
Vaginally both preffered
Buccal
Rectal
Sublingual
What receptor does Mesoprostol interact with in the GI
EP 1
What is the gastroprotection mechanism of misoprostol
Increase secretion of mucus and bicarbonate.
And inhibit gastric secretion
Factors that stimulate gastric acid secretion
Histamine
Alcohol
Food
NSAIDs
Caffeine
What is the limitation to the use of misoprostol in the treatment of GI ulcer
Adverse effect
Diarrhoea
Abdominal cramps
And its daily use
