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Intro B Pharmacology > CNS pharmacology > Flashcards

CNS pharmacology Flashcards

1
Q

What is the principal integrating region for the ANS

A

Hypothalamus

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2
Q

List the functions of the hypothalamus

A

Sleep
Blood pressure
Sexual and circadian rhythm
Secretion by the hypothalamus
Temperature
Water balance
Emotion
Intermediary metabolism

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3
Q

List the functions of the cerebellum

A

Complex movements
Talking
Walking
Posture
Balance
Reflex
Fine coordinated movement
Learning
Memory

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4
Q

The main function of the spinal cord is

A

Conduction and reflex centre

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5
Q

The axon is characterised by very high concentration of ……..

A

Voltage gated Na channel

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6
Q

Graded potential transmits over short distances and are activated by ….. action potential are activated by …..

A

Mechanical and chemical channel

Voltage

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7
Q

How is glutamate released into the synapse

A

Through calcium dependent exocytosis

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8
Q

The two class of receptors used by glutamate

A

Metabotropic
Ionotropic

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9
Q

The glutamate ionotropic receptors are

A

NMDA
KA
AMPA

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10
Q

Glutamate is inhibited by

A

Strychnine

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11
Q

GABA B is inhibitory and it carries out its action by

A

Inhibition of ca entry
Activate k+
Inhibit adenylase cyclase

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12
Q

The drugs that inhibt GABA A include

A

Picrotoxin
Bicuculine

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13
Q

What was the first neurotransmitter identified pharmacologically the CNS

A

Acetylcholine

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14
Q

Acetylcholine has both stimulatory and inhibitory function cite an example

A

M1 excitatory
M2 inhibitory

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15
Q

The dopaminogernic receptors are

A

D1 like (D1, D5)
D2 like D 3 4 5)

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16
Q

The cerebral hemispheres carry out functions of

A

Logical reasoning
Moral conduct
Sensory interpretation
Initiation of voluntary muscle action

17
Q

Thalamus and basal ganglia together regulate …………. function

A

Visceral

18
Q

How many pairs of spinal nerve is contained in the spinal cord

A

31 pairs

19
Q

The membrane potential of the neuron is ……….

A

-70mv

20
Q

The acidic neurotransmitters are

A

GABA
Glycine

21
Q

Glutamate metabotropic neurotransmitters are

A

GPCR I presynaptic

GPCR II and III post synaptic ( inhibitory)

22
Q

The CNS neurotransmitters and their major function

A

Adrenaline -fight/flight
Acetylcholine- learning
Glutamate-Memory
GABA-calming
Noradrenaline - concentration
Endorphins -Euphoria
Serotonin- mood
Dopamine- pleasure

Intro B Pharmacology (24 decks)

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