Anti Psychotics Flashcards
The receptor responsible for the action of antipsychotic drug is
D2 receptor
List the classes of typical antipsychotics
Phenothiazenes
Butyrophenone
Thioxanthenes
Diphenylbutylpiperidines
Dihydroindolone derivatives
Dibenzoxapene
Substituted Benzamides
The phenothiazenes include
Chlorpromazine
Thioridazine
Fluphenazine
Promethazine
Promazine
Phenothiazine
Trifluoperazine
The Butyrophenones are
Haloperidol
Droperidol
Benperidol
Tthioxanthenes are …….
Thiothixene
Flupenthixol
Zuclopenthixol
Diphenylbutylpiperidines are
Pimoxide
Fluspirilene
Atypical (second generation)
Amisulpiride
Clozapine
Risperidone
Olanzapine
Quetiapine
Sertindole
Clozapine
Xotepine
The phenothiazenes derivative are
Propylamine derivatives with aliphatic side chain
Piperidyl derivatives: have piperidine side chain
Polypiperazine derivatives:piperazine side shain
The order of improvements of phenothiazenes are
Sedative effects reduce down the generation
Antimuscarinic effect is more pronounced grp 2
Extrapyramidal side effects is pronounced in grp 3
Pharmacological effects of phenothiazenes include
Behavioural effects
Autonomic nervous system effect
Cardiac effect
Antiemetic effect
Extrapyramidal effect
Endocrine effect
Lowered seizure threshold
Toxic confusion also state
Sedation is not a necessary antipsychotic effect, why?
Tolerance develops to psychotic effect
Some piperazine derivatives like Prochlorperazine, trifluoperazine and Fluphenazine have no sedative effect
A peculiar side effect of atypical anti-psychotic are
Weight gain
Metabolic imbalance
