Androgens

Question 1

The precursors for androgen are

Answer 1

Dehydroepiandrosterone
Androstenedione

Question 2

Precursors of testosterone are converted to testosterone in the ………

Answer 2

Liver

Question 3

Testosterone that cannot be converted to DHT is functional in ……..

Answer 3

Muscle

Question 4

Testosterone is metabolised to DHT in which organs ……

Answer 4

Skin
Seminal vesicle
Prostate gland
Epididymis

Question 5

What is the effect of androgen on pre pubertal males

Answer 5

It results in growth retardation due to fusion of epiphyses.

Question 6

The half life of testosterone is ……

Answer 6

10-21mins

Question 7

The route of administration of testosterone is

Answer 7

Subcutaneous
Transdermal
Topical

Question 8

Why is testosterone ineffective orally

Answer 8

Due to extensive first pass metabolism

Question 9

What synthetic modifications is done to testosterone to increase its function

Answer 9

Addition of esterified lipid

Question 10

Semi Synthetic testosterone are

Answer 10

Testosterone undecanoate
T. Ecanthoate
T. Propionate
T.cypionate

Question 11

How are semi synthetic testosterone administered

Answer 11

Intramuscular injection and the esters hydrolyse at the site of injection to increase absorption

Question 12

Testosterone undecanoate can be administered orally T/F

Answer 12

True

Question 13

The ratio of anabolic to androgenic function in testosterone and its esters is

Answer 13

1:1

Question 14

Mesterelone and fluoxymesterone is administered through …..

Answer 14

Orally

Question 15

Methyl testosterone is administered ……

Answer 15

Orally, sublingually

Question 16

Mesterelone is not preferred in treatment of reproductive issue, why?

Answer 16

It has an androgenic to anabolic ratio of 1:2
Less converted to DHT

Question 17

Danazol is …..

Answer 17

2,3 isoxazol 17 aethynl testosterone

Question 18

Synthetic testosterone include

Answer 18

Mesterelone
Fluoxymesterone
Danazol
Methyl testosterone