Antihistamines

Question 1

Burimamide is a H2 receptor non selective antagonist T/F

Answer 1

True

Question 2

H2 antagonist are

Answer 2

Famotidine
Ranitidine
Cimetidine
Nizatidine

Question 3

An example of an H3 receptor antagonist is ………… and it is used in the treatment of ……….

Answer 3

Pitolisant /tripolisant
Narcolepsy

Question 4

Selective H3 receptors include

Answer 4

Thioperamide
Clobenpropit

Question 5

Clobenpropit is an agonist at ………….. receptors and an inverse agonist at ………. receptors

Answer 5

H4
H3

Question 6

The histamine receptors found in the human Airways are

Answer 6

H1 and H2

Question 7

N type Ca channels are involved in the release of neurotransmitter such as

Answer 7

GABA
Glutamate
Acetylcholine
Dopamine
norepinephrine

Question 8

The second generation histamines find it difficult to cross the BBB

Answer 8

Less lipophillic
Substrate for p glycoprotein

Question 9

The first generation antihistamines are stable amines and are rendered lipophillic by presence of ……….

Answer 9

Aromatic and alkyl substituent

Question 10

The histamines and their metabolites that are available as drugs are

Answer 10

Hydroxyzine - cetrizine
Terfenadine -Fexofenadine
Loratidine - desloratidine

Question 11

The first generation antihistamines can also bind to other receptors like ……..

Answer 11

Cholinergic
Muscarinic
Alpha 1 adrenergic
Serotonergic
Receptors

Question 12

Antihistamines which can be used in the treatment of motion sickness include

Answer 12

Dimenhydrinate
Diphenhydramine
Meclizine
Hydroxyzine
Promethazine

Question 13

The first generation antihistamines that can’t result in sedation are

Answer 13

Dimenhydrinate
Meclizine