Heavy Metal

Question 1

How does heavy metal poisoning happen

Answer 1

Inactivation of an enzyme by binding to one or more ligand of the enzyme

Forming complexes with important biological radicals like
Sulfhydryl Hydroxyl
Carboxyl
Amino acid
Imidazole

Question 2

The route of administration of lead is
………

Answer 2

Inorganic lead GI tract and Respiratory tract
Organic lead: skin, Git and RT

Question 3

Absorption of lead is improved by ………..

Answer 3

Empty stomach
Low dietary calcium
Increased by iron deficiency

Question 4

Lead’s half life is……

Answer 4

1-2months in blood and soft tissue

Question 5

The MOA of lead is

Answer 5

Inhibition of enzyme
Interfering with activities of cation e.g ca2+ Fe2+

Altering the structure of cell membrane and cell receptors

Question 6

How is lead poisoning treated

Answer 6

Decontaminate and prevent further exposure
Provide support care
Administer chelating agent

Question 7

How is lead encephalopathy treated

Answer 7

Administration of corticosteroids and mannitol to reduce cerebral oedema
Anticonvulsant to treat seizure

Question 8

Explain Chelation therapy

Answer 8

Edetate calcium disodium IM/IV or dimecarpol IM for 5 days followed by succimer