Anti Angina Drugs Flashcards
What is the primary goal of anti-angina drugs?
To relieve or prevent angina symptoms by improving blood flow to the heart.
True or False: Anti-angina drugs are used to treat high blood pressure.
False
Which class of anti-angina drugs work by dilating blood vessels to increase blood flow to the heart?
Calcium channel blockers
What is the main mechanism of action for nitrates in treating angina?
They dilate blood vessels to increase blood flow to the heart.
Which type of anti-angina drug is commonly used as a first-line treatment for stable angina?
Beta blockers
What is the primary adverse effect of nitrates?
Headache
Which anti-angina drug class should be avoided in patients with heart failure?
Calcium channel blockers
What is the main goal of using anti-angina drugs in patients with unstable angina?
To prevent heart attacks
True or False: Anti-angina drugs can help reduce the frequency and severity of angina attacks.
True
Which anti-angina drug class is known for its negative inotropic effects?
Beta blockers
What is the primary mechanism of action for beta blockers in treating angina?
They reduce the heart rate and workload on the heart.
Which anti-angina drug class works by inhibiting the action of angiotensin-converting enzyme (ACE) to reduce blood pressure?
ACE inhibitors
What is the main side effect of calcium channel blockers?
Peripheral edema
True or False: Anti-angina drugs are used to treat coronary artery disease.
True
Which anti-angina drug class should be avoided in patients with asthma?
Beta blockers
What is the primary mechanism of action for ACE inhibitors in treating angina?
They reduce blood pressure and workload on the heart.
Which anti-angina drug class is commonly used for variant (Prinzmetal) angina?
Calcium channel blockers
What is the main side effect of ACE inhibitors?
Dry cough
True or False: Anti-angina drugs are used to treat heart failure.
False
Which anti-angina drug class should be avoided in patients with peripheral artery disease?
Beta blockers
What is the primary mechanism of action for calcium channel blockers in treating angina?
They relax and widen blood vessels to improve blood flow.
Which anti-angina drug class can cause reflex tachycardia as a side effect?
Nitrates
What is the main side effect of beta blockers in treating angina?
Bradycardia
True or False: Anti-angina drugs are used to treat arrhythmias.
False
Factors that can lead to increased oxygen consumption in the heart include
Increased; heart rate
Contractility
Preload
Afterload
Factors that can lead to decreased blood flow to the heart include
Vasospasm
Fixed stenosis
Thrombosis
Classify angina based on reduced coronary blood flow
Printzmetal’s variant angina
Vasospasm
Supply ischemia
Chronic stable
Fixed stenosis
Demand ischemia
Unstable
Thrombosis
Supply ischemia
Describe the MOA OF nitrates
Nitrate to NO
NO activates guanylyl cyclase
GC converts GTP to cGMP
cGMP activates cGMP-dependent protein kinase
CGMP-dependent protein kinase activates MLC Phosphates.
This then cleaves Phosphate from MLC
This results in relaxation and Decreased venous return to the heart
