Depression Flashcards
Forms of depressions include
UMD unipolar major depression
PDD
Persistent depressive disorder dysthymia
Premenstrual dysphoria disorder
Depression associated with other disorders
What does the monoamine theory suggest
It suggests that two main neurotransmitters involved are norepinephrine and serotonin reduction results in depression
Current antidepressants have effect ..
………. on serotonin and norepinephrine
Effect on
Metabolism
Reuptake
Or selective reuptake antagonism
Except brupopion
The classes of drugs used in treatment of serotonin include
SSRIs
SNRIs
MOA inhibitors
Tricyclic antidepressants
Atypical antidepressants
Serotonin modulators
Example of SSRIs are
Setraline
Fluoxetine
Paroxetine
Fluvoxamine
EsCitalopram
Citalopram
The lack of serotonin reuptake results in
Activation of adenylase cyclase
Promote neurogenesis
Trophic effect of increasing the expression of BDNF brain-derived neurotrophic factors
The side effects of SSRIs include
Headache
Sexual discomfort
QT prolongation
SNRIs include
Venlafaxine
Desvenlafaxine
Milnacipran
Levomilnacipran
Duloxetine
The SSNRIs selective for norepinephrine reuptake is…….
Milnacipran
Levomilnacipran
SSNRIs are used for the treatment of
Panic disorder
Anxiety
Neuropathy
Side effect of NSSRIs are
Increase BP and HR
Bone resorption
Tricyclic antidepressants include
Amitriptyline
Napotriptyline
Mapotriptyline
Protriptyline
Imipramine
Chlopropramine
Desipramine
Amoxapine
Doxepin
The tricyclic that is selective for norepinephrine is
Desipramine
The tricyclic used majorly in the treatment of depression include
Amoxapine
Natriptyline
Mapotriptyline
Tricyclic antidepressants include
Natriptyline and amitriptyline.
