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Intro B Pharmacology > CNS stimulant > Flashcards

CNS stimulant Flashcards

1
Q

The examples of CNS stimulants are

A

Picrotoxin
Bicuculine
Strychnine
PTZ pentenyltetrazol

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2
Q

The convulsions produced by strychnine is …….

A

Tonic clonic contraction
Symmetrical

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3
Q

Why is strychnine called a spinal convulsant

A

The conc that produces convulsion in spinal animals is the same in intact animals

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4
Q

MOA of strychnine

A

It blocks the action or glycine at the postsynaptic membrane

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5
Q

Uses of strychnine

A

Purgatives
Aphrodisiac
Appetite suppressant
Constituent of nerve tonics

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6
Q

Strychnine effect mimics…….

A

Tetanus effect

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7
Q

Opisthotonus position

A

Hyperextension of the spinal cord

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8
Q

The convulsions of strychnine are

A

Clonic
Asymmetrical contraction
Spontaneous

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9
Q

MOA of picrotroxin

A

Presynaptic inhibition of GABA receptor
It doesn’t bind directly to the receptor but inhibit chloride channel from opening

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Intro B Pharmacology (38 decks)

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