Drug Treatment For PUD

Question 1

List the 10 possible causes of PUD

Answer 1

1. H. Pylori
2. NSAIDS
3. Glucocorticoids
4. Family history 5.zollinger Ellison syndrome
5. Smoking
6. Stress
7. Excess alcohol intake
8. Blood group O
9. Hyperparathyroidism

Question 2

The two categories of drugs for the treatment pf PUD are

Answer 2

1. Drugs that inhibit reduce or neutralise gastric acid secretion
2. Drugs that promote the mucosa defense

Question 3

The drugs that can treat PUD by affecting the stomach acid include

Answer 3

Antacids
Antihistamines
Proton pump inhibitor
Muscarinic antagonist

Question 4

The antacids an their side effects

Answer 4

NaHCO3
Unreached alkali-metabolic alkalosis
Co2 - gastric distention and belching
NaCl- fluid retention hypertension, renal failure

CaCO3

Milk alkali syndrome
Hypercalcemia
Metabolic alkalosis
Renal impairment

Gastric distention
Belching

Question 5

The peculiarities of Mg/Al OH salts are

Answer 5

No gastric distention and belching
No metabolic Alkalosis

Side effects
Lack of absorption of salts
Al -constipation
Mg-osmotic diarrhoea
Renal impairment due to absorption of Mg and Cl in the kidney
It prevents the absorption of phosphate by binding phosphate in the git. This affects the bones.

Question 6

The side effects of magnesium trisillicate salts

Answer 6

Drug-Drug interaction

Increased pH
Chelation of drugs like ketoconazole ,itracnazole, tetracycline

Question 7

The duration of action of antacids on an empty stomach is ………..

Answer 7

30 mins

Question 8

Slow gastric emptying favours the action of antacids T/F

Answer 8

True
It prolongs their duration of action 2
-3 hrs

Question 9

Briefly describe the pharmacokinetics of H2 antihistamines

Answer 9

Excreted unchanged in the urine
Half life of 10 hours
Twice daily

Question 10

Sucralfate is nor effective in the treatment of NSAID induced gastric ulcer T/F

Answer 10

True

Question 11

Sucrafalte adverse effect include

Answer 11

Dietary phosphate- dietary phosphate deficiency

Phenytoin -reduced absorption
Drugs quinolone warfarin, antibiotics

Question 12

The pharmacokinetics of misoprostol is ………..

Answer 12

Rapidly absorbed
Half life <30 mins
Excreted in the urine

Question 13

Bismuth solutions include

Answer 13

Bismuth dinitrate
Bismuth subcitrate
Bismuth salicylate
Bismuthate
Tripotassium dicitrato

Question 14

Bismuth results in toxicity such as encephalopathy ( Ataxiaerc except

Answer 14

Bismuth citrate
Bismuth subsalicylate - salicylate toxicity

Question 15

The anti muscarinic involved in the inhibition of gastric acid secretion include …………… and they inhibit ……….. receptors

Answer 15

Pirenzapine
Telenzapine

Question 16

Pirenzapine has more cytoprotective property than antihistamines T/F

Answer 16

True

Question 17

Is it true that muscarinic antagonist have a diminished use in the treatment of PUD

Answer 17

True

Question 18

What is the difference between a potassium competitive acid inhibitor and a PPI

Answer 18

They inhibit the k+enzyme of a proton pump in a reversible manner

They do not require acid for their activation.
More safety margin