Finrinolytic Agents And Antiplatelets Flashcards
Streptokinase is also known as
Kabikinase or streptase
Streptokinase is derived from ………
B hemolytic streptococcus
The site at which plasminogen binds to fibrin is rich in
Lysine
Alpha 2 antiplasmin binds covalently to fibrin T/F
True
Fibrinolytic drugs are also called ……..
Clot busters
Fibrinolytic agents have a higher risk of hemorrhage T/F
True
Indications for fibrinolytic therapy include
Acute ischemic stroke
Acute myocardial infarction
Deep venous Thrombosis
Pulmonary embolism
Peripheral artery occlusion
Plasmin is capable of breaking down
Fibrin
Fibrinogen
Factor v
Factor viii
The action of plasmin can be specific or non specific
It is non specific in fluid state as it doesn’t bind fibrin
It is specific when bound to fibrin breaking it down
The non-fibrin specific fibrinolytic drug are
Streptokinase
Urokinase
Anistreptlase
The nonspecific fibrinolytic drugs are tissue plasminogen activators, list them
Alteplase
Reteplase
Tenecteplase
Differentiate between nonspecific and specific fibrinolytic drugs
Nonspecific fibrinolytic drugs can bind fibrin both in fluid state and when tissue-specific I.e circulating and non-circulating
Hence it can result in local fibrinolysis
Systemic fibrinolysis
For the nonspecific fibrinolytic agents, they are synonymous with the tPAs
They are specific and selective
Tissue clot specific
Selective for non-circulating plasminogen
Hence there’s a reduced likeliness for bleeding to occur
Streptokinase and plasminogen form
The activator complex
What is the least expensive fibrinolytic drug
Streptokinase
Half-life of sk is
20 min
The method of administration of SK is
250,000-100,000 U /hrs
42-72hrs
Indications for usage of streptokinase is
Transmural MI
DVT
Venous or arterial embolism
Adverse effect of streptokinase include
Allergic runs
Bronchospasm
Breathing difficulties
Itching
Rash
Flushing
Hemorrhage
Another name for anistreplace is …….
APSAC
Anisoylated streptokinase activator complex
Anistreplace is composed of
Activator complex blocked by an anisoyl group
Anistreplace is a prodrug T/F
True
Anistreplace is a prodrug that undergoes ………
Decoration to form the activation complex
Anistreplace has a longer half life of ……… compared to the short half life of streptokinase
70-120 minutes
Anistreplace is administered through
IV injection
2-5 minutes in a dose of 30 units
The advantages of anistreplase over streptokinase are
Longer duration of action
Better effect
But more expensive
Indications and adverse effect of anistreplase include
Acute myocardial infarction
Adverse effect
Hemorrhage
Urokinase is derived from
Urine
Culture of human embryonic kidney cells
MOA of Urokinase
Acts directly to convert plasminogen to active plasmin
Urokinase is administered through
IV infusion
300, 000 U over 10 mins
300, 000 U/hrs
The elimination half life of Urokinase id
12-20 min
The indications for Urokinase include
Acute massive pulmonary embolism
Coronary artery Thrombosis IV catheter clearance
The adverse effect of Urokinase is
Hemorrhage
Allergic reactions
All tPAs are genetically engineered version of human tPA T/F
True
Recombinant tPA is ……. Times more potent at activating fibrin bound plasminogen than circulating plasminogen
100 fold
The half life of recombinant tPA is …….
5-10mins
tPA is non antigenic T/F
True
