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Intro B Pharmacology > Finrinolytic Agents And Antiplatelets > Flashcards

Finrinolytic Agents And Antiplatelets Flashcards

1
Q

Streptokinase is also known as

A

Kabikinase or streptase

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2
Q

Streptokinase is derived from ………

A

B hemolytic streptococcus

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3
Q

The site at which plasminogen binds to fibrin is rich in

A

Lysine

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4
Q

Alpha 2 antiplasmin binds covalently to fibrin T/F

A

True

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5
Q

Fibrinolytic drugs are also called ……..

A

Clot busters

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6
Q

Fibrinolytic agents have a higher risk of hemorrhage T/F

A

True

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7
Q

Indications for fibrinolytic therapy include

A

Acute ischemic stroke
Acute myocardial infarction
Deep venous Thrombosis
Pulmonary embolism
Peripheral artery occlusion

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8
Q

Plasmin is capable of breaking down

A

Fibrin
Fibrinogen
Factor v
Factor viii

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9
Q

The action of plasmin can be specific or non specific

A

It is non specific in fluid state as it doesn’t bind fibrin
It is specific when bound to fibrin breaking it down

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10
Q

The non-fibrin specific fibrinolytic drug are

A

Streptokinase
Urokinase
Anistreptlase

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11
Q

The nonspecific fibrinolytic drugs are tissue plasminogen activators, list them

A

Alteplase
Reteplase
Tenecteplase

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12
Q

Differentiate between nonspecific and specific fibrinolytic drugs

A

Nonspecific fibrinolytic drugs can bind fibrin both in fluid state and when tissue-specific I.e circulating and non-circulating

Hence it can result in local fibrinolysis
Systemic fibrinolysis

For the nonspecific fibrinolytic agents, they are synonymous with the tPAs
They are specific and selective

Tissue clot specific
Selective for non-circulating plasminogen
Hence there’s a reduced likeliness for bleeding to occur

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13
Q

Streptokinase and plasminogen form

A

The activator complex

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14
Q

What is the least expensive fibrinolytic drug

A

Streptokinase

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15
Q

Half-life of sk is

A

20 min

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16
Q

The method of administration of SK is

A

250,000-100,000 U /hrs
42-72hrs

17
Q

Indications for usage of streptokinase is

A

Transmural MI
DVT
Venous or arterial embolism

18
Q

Adverse effect of streptokinase include

A

Allergic runs
Bronchospasm
Breathing difficulties
Itching
Rash
Flushing

Hemorrhage

19
Q

Another name for anistreplace is …….

A

APSAC
Anisoylated streptokinase activator complex

20
Q

Anistreplace is composed of

A

Activator complex blocked by an anisoyl group

21
Q

Anistreplace is a prodrug T/F

A

True

22
Q

Anistreplace is a prodrug that undergoes ………

A

Decoration to form the activation complex

23
Q

Anistreplace has a longer half life of ……… compared to the short half life of streptokinase

A

70-120 minutes

24
Q

Anistreplace is administered through

A

IV injection

2-5 minutes in a dose of 30 units

25
Q

The advantages of anistreplase over streptokinase are

A

Longer duration of action
Better effect
But more expensive

26
Q

Indications and adverse effect of anistreplase include

A

Acute myocardial infarction

Adverse effect
Hemorrhage

27
Q

Urokinase is derived from

A

Urine
Culture of human embryonic kidney cells

28
Q

MOA of Urokinase

A

Acts directly to convert plasminogen to active plasmin

29
Q

Urokinase is administered through

A

IV infusion
300, 000 U over 10 mins
300, 000 U/hrs

30
Q

The elimination half life of Urokinase id

A

12-20 min

31
Q

The indications for Urokinase include

A

Acute massive pulmonary embolism
Coronary artery Thrombosis IV catheter clearance

32
Q

The adverse effect of Urokinase is

A

Hemorrhage
Allergic reactions

33
Q

All tPAs are genetically engineered version of human tPA T/F

A

True

34
Q

Recombinant tPA is ……. Times more potent at activating fibrin bound plasminogen than circulating plasminogen

A

100 fold

35
Q

The half life of recombinant tPA is …….

A

5-10mins

36
Q

tPA is non antigenic T/F

A

True

Intro B Pharmacology (24 decks)

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