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Intro B Pharmacology > Oral Hypoglycemic Agent > Flashcards

Oral Hypoglycemic Agent Flashcards

1
Q

The 1st generation sulfonyureas are

A

Tolbutamide
Chlopropamide

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2
Q

The 2nd generation sulfonyureas are

A

Glipizide
Glimipride
Glyburide

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3
Q

The indications and contraindications of sulfonyureas are

A

MODY -3
Type 2 diabetes
Neonatal diabetes

Contraindications
Type 1 diabetes
Pregnancy
Lactation
Significant Hepatic and renal failure

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4
Q

Side effect of sulfonyureas

A

Weight gain
Hypoglycemic
Hyperinsulinemia
Nausea
Vomiting
Agranulocytosis
Aplastic

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5
Q

Drug - interactions of sulfonyureas

A

Increase activity
Sulfonamide
Clofibrate
Salicylate
Probenecid
Clarithromycin
Chloramphenicol
MOA inhibitors
B blockers

Decrease activity
Atypical antipsychotics
Diuretics

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6
Q

The MOA of insulin sensitizers ( biguanides)

A

Decrease Gluconeogenesis
Slows intestinal absorption of sugar
Inhibits glucagon action

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Intro B Pharmacology (38 decks)

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