Prochlorperazine Drug sheet

Question 1

What is the mode of action?

Answer 1

Dopamine antagonist- antiemetic effects are primarily due to D2 receptor blockage. Also acts on other neurotransmitter systems including histaminic, cholinergic and alpha adrenaline receptors.

Question 2

What are the indications?

Answer 2

Nausea and vomiting in paitents 21 and over specifically for

• allergy/contra ondansetrone and vestibular nausea
• Headache

Question 3

What are the contraindications?

Answer 3

CNS depression (unconcious or sevre intoxicated)

Question 4

What are the precautions?

Answer 4

Children and young adults more suseptible to extrapyramidal symtoms. Avoid use in paitens <21
Elderly paitnets- more suseptable to advrse effects.
Parkinsons disease- can worse symptoms of parkinsons, avoid if possible

Question 5

What are the adverse effects?

Answer 5

CNS sedatiion and blurred vison
CV posterial hypotension, QT prolongation (rare)
Extrapyramadal reactions

Question 6

Is it safe to use with pregant and breast feeding?

Answer 6

Pregnant- yes if administered in approved doses. High/prologned doses in later preganacy may increase risk of withdrawl effects in newborn

Breastfeed- yes

Question 7

What is the presentation, route of admission, onset and duration?

Answer 7

12.5mg in 1ml
IM
Onset- 10-20 minutes
Duration - 3-4 hours

Question 8

What is included in the notes of this drug sheet?

Answer 8

ampuole needs protection from the light

Solution should be white or pale yellow-dark yellow should not be administered