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Undeleted > Pharm > Flashcards

Pharm Flashcards

1
Q

Half life eqn

A

t(half)=0.7*Vd/CL

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2
Q

Volume of distribution eqn

A

Vd=amt in body/plasma conc

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3
Q

Clearance eqn

A

CL=rate of elimination/plasma conc

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4
Q

Loading dose eqn

A

LD=Cp*(Vd/F)

Cp=target plasma conc

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5
Q

Maintenance dose eqn

A

MD=Cp*CL/F

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6
Q

Half lives to reach steady state

A

4-5

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7
Q

Action of competitive antagonist

A

decreases potency

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8
Q

Action of noncompetitive antagonist

A

decrease efficacy

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9
Q

Nicotinic receptors

A

ACh
Na+/K+ channels
Nn on autonomic ganglia
Nm on NMJ

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10
Q

Muscarinic receptors

A 
ACh
G protein coupled
M1-CNS, Gq
M2-heart, Gi
M3-smooth m., endocrine, accomodation, Gq
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11
Q

D1 receptor

A

relaxes renal vascular smooth m.

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12
Q

D2 receptor

A

modulates CNS neurotransmitters

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13
Q

Bethanechol use

A

activates bowel/bladder smooth m.

ACh agonist

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14
Q

Carbachol use

A

glaucoma/decreases intraocular P

Ach agonist

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15
Q

Pilocarpine use

A

open and closed angle glaucoma

contracts ciliary m. and pupillary sphincter

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16
Q

Uses of anticholintesterases

A

Myasthenia gravis/anticholinergic toxicity
Neostigmine/pyridostigmine
edrophonium/physostigmine/donepezil

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17
Q

Use for physostigmine

A

anticholinergic toxicity

crosses BBB

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18
Q

Use of donepezil

A

Alzheimer’s disease

anticholinesterase action

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19
Q

Antidote for anticholinergic agents

A

atropine + pralidoxime

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20
Q

Muscarinic antagonists

A 
atropine/tropicamide
benztropine
scpolamine
ipratropium/tiotropium
oxybutynin
glycopyrrolate
21
Q

Use of Benztropine

A

Parkinson’s disease

ACh antagonist

22
Q

Use of scopolamine

A

motion sickness

ACh antagonist

23
Q

Use of atropine/tropicamide

A

pupil dilation

24
Q

Risk with atropine

A

can cause acute angle closure glaucoma in elderly

due to pupil dilation

25
Q

Terbutaline

A

beta agonist

can reduce premature uterine contractions

26
Q

Central acting alpha2 agonists

A

clonidine

alpha-methyldopa

27
Q

Use of phenoxybenzamine

A

pheochromocytoma
alpha blocker (irreversible)
phentolamine is reversible

28
Q

Use of mirtazapine

A

for depression
alpha 2 antagonist
also increases apetite

29
Q

Beta-1 selective antagonists

A 
acebutolol
betaxolol
esmolol
atenolol
metoprolol
MABES
30
Q

Nonselective beta antagonists

A

propranolol
timolol
nadolol
pindolol

31
Q

Nonselective alpha/beta antagonists

A

carvedilol

labetalol

32
Q

Tx for digitalis OD

A

Lidocaine
Abs to dig
Mg2+

33
Q

Tx for lead poisoning

A

dimercaprol/succimer/CaEDTA

34
Q

Tx for iron overload

A

deferoxamine

35
Q

Tx for Hg/Arsenic/gold OD

A

dimercaprol/succimer

36
Q

Tx for Copper OD

A

penicillamine

37
Q

Tx for cyanide poisoning

A

nitrite + thiosulfate

38
Q

Tx for methanol poisoning

A

fomepizole

39
Q

Tx for benzodiazepine OD

A

flumazenil

40
Q

Drugs causing flushing

A

vancomycin
niacin
CCB’s

41
Q

Drug causing dilated cardiomyopathy

A

doxorubicin

42
Q

Drugs causing torsades de pointes

A

Class IA and III antiarrhythmics

43
Q

Drugs causing hemolysis in G6PD deficiency

A 
INH
sulfa drugs
primaquine
aspirin
ibuprofen
nitrofurantoin
44
Q

Drugs causing pulmonary fibrosis

A

amiodarone
bleomycin
busulfan

45
Q

Drugs causing gingival hyperplasia

A

phenytoin

verapamil

46
Q

Tendon rupture adverse effect drug

A

fluoroquinolones

47
Q

Drugs inducing CYP450

A 
barbiturates
St John's Wort
phenytoin
rifampin
excess EtOH intake
48
Q

Drugs inhibiting CYP450

A 
macrolides
grapefruit juice
isoniazid
ketoconazole
quinidine

Undeleted (71 decks)

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