Immunology Mediator roles Flashcards
IL-1 role
proinflammatory
acute phase protein induction/fever
stimulates Th cells/hepatocytes/hypothalamus
IL-2 role
proliferation/enhanced killing of cytotoxic T cells
secreted by Th1 cells
IL-3 role
growth factor of hematopoietic cells
secreted by Th cells
IL-4 role
class switching to IgE and IgG secreted by Th2 cells onto B cells
IL-5 role
class switching to IgA secreted by Th2 cells onto B cells
IL-6 role
proinflammatory
acute phase protein induction/fever
plasma cell differentiation and Ab production
secreted by macrophages and Th2 cells
IL-7 role
differentiation
secreted by bone marrow/thymus
impacts B and T cell precursors
IL-8 role
chemotaxis of neutrophils
secreted by macrophages
IL-10 role
decrease inflammation
secreted by macrophages
IL-12 role
differentiation from Th cells to Th1 cells
secreted by macrophages
Role of IFN-alpha and IFN-beta
inhibit viral replication
secreted by leukocytes and fibroblasts
Role of IFN-gamma
activation of macrophages
secreted by Th1 cells
Role of TNF-alpha
induces cytokine secretion (proinflammatory)/cachexia
secreted by macrophages
What can IFN-gamma tx?
chronic granulomatous disease
What can IFN-beta tx?
multiple sclerosis
