Immuno receptor and cell type roles Flashcards
1
Q
CD3 role
A
on T cells
T cell differentiation and activation
2
Q
T cell receptors
A
TCR
interacts with MHC II
3
Q
MHC class I
A
present endogenous Ags to Tc cells (viruses)
on all nucleated cells
recognized by CD8
4
Q
MHC class II
A
present exogenous Ags to Th cells (bacteria/etc)
in all Ag presenting cells (APCs)
recognized by CD4
5
Q
Cell type with CD4
A
T helper cells
6
Q
Cell type with CD8
A
Cytotoxic T cells (CTLs)
7
Q
Th0 cells
A
can differentiate into Th1 or Th2
8
Q
Th1 cells
A
cell mediated immunity
CD8 (CTL’s) delayed hypersensitivity
downregulates Th2 cells
9
Q
Th2 cells
A
humoral immunity
stimulate Ab production
class switching
downregulates Th1 cells
10
Q
Treg cells
A
limits activation of T cells
11
Q
Th17 cells
A
clearance of pathogens not handled by Th1 or Th2 cells
potent inflammatory/autoimmunity
