Pathology - Inflammation Flashcards
Leukotrienes activate….
Activate neutrophils!
Cell type responsible for the immidiate response
Mast cells
Following IgE binding or complement binding.
classic complement pathway
C1 binds IgG or IgM bound to an antigen
Alternative pathway
Microbial antigens directly activate the pathway.
Mannose binding lecithin
MBL binds to mannose on microorganisms activating the pathways.
All complement pathways produce…
C3 convertase that produces C5 convertase (C5B forms the MAC)
Hageman Factor XII
Inactive proinflammatory protein from the liver activated by exposure to the subendothelia or tissue collagen.
cardinal signs of inflamamtion
Rubor
Calor
Dolor
Palor
What protein allows leukocytes to roll along the vessels?
Selectins.
What proteins allow for adhesion of leukocytes in inflamamtion?
ICAM and VCAM as well as Integrins.
Chediak Higashi syndrome?
Autosomal recessive
Impaired phagolysosome formation clinically presenting with pyogenic infections, neutropenia, albinism, neuropathy etc.
Chronic granulomatous disease
Poor O2 dependent killing due to a defect in NADPH oxidase.
