Biochemistry nutrition Flashcards
Fat soluble vitamins
A D E K
Name the following vitamins B1 B2 B3 B5 B6 B7 B9 B12 C
1 Thiamine 2 Riboflavin 3 Niacin 5 Pantathenic acid 5 Pyridoxine 7 Biotin 9 Folate 12 Cobalamin C Ascorbic acid
Vitamin A deficiency
Night blindness
Scaly dry skin and bitot conjunctiva spots.
Vitamin B1 deficiency
thiamine deficieny Strongly related to the TCA cycle LEads to wernicke korsakof syndrome Dry beriberi Wet beri beri
Due to impaired lucose breakdown/ATP depletion.
Wernicke korsakoff syndrome
confusion, opthalmoplegia, and ataxia are the classic triad.
thiamine deficiency/B1
Dry Beri Bery
Secondary to thiamine deficiency (B1)
Polyneuritis, symmetrical muscle wasting.
Wet Beri Beri
High output cardiac failure (dilated cardiomyopathy), edema.
Secondary to thiamine (B1) deficiency.
Vitamin B2 (riboflavin) deficiency
FAD and FMN cofactor deficiency.
Leads to cheilosis (inflammation of lips, scaling and fissures at corners of the mouth)
and corneal vascularization.
“The 2 C’s of B2”
Vitamin B3 deficiency
Niacin deficiencyies result in lack of NAD and NADP+ formation. Derived from tryptophan. Synthesis requires B2 and B6.
Deficiency results in glossitis, pellagra.
Pellagra
Niacin B3 deficiency
Diarrhea
dementia
Dermatitis -> Broad collar rash
Vitamin B5 deficiency
Essential for Co-enzyme A and fatty acid synthesis
Dermatitis, enteritis, alopecia, and adrenal deficiency occurs.
Vitamin B6 (pyridoxine) deficiency
Used for the creation of many catecholamines.
Leads to convulsions, hyperirritibility, peripheral neurppathy and sideroblastic anemias.
B7 (biotin deficiency)
Cofactor for the carboxylation enzymes
deficiencies are rare, but leads to dermatitis, alopecia, enteritis.
Vitamin B9 Folate deficiency
Converted to THF important for DNA and RNA formation.
Leads to macrocytic and megaloblastic anemia. Homocysteine levels will be high in lab results.
Vitamin B12 deficiency
Macrocytic, megaloblastic anemia
Hypersegmented PMNs
formed through animal products and stored in the liver.
requires intrinsic factor to pick up from the intestine.
