naloxone

Question 1

Trade name for naloxone

Answer 1

Narcan

Question 2

Class for naloxone

Answer 2

Narcotic antagonist

Question 3

Standard supply for naloxone

Answer 3

Prefilled syringe

Question 4

MOA for naloxone

Answer 4

Acts as a competitive antagonist at opiate receptors in the central nervous system
Reverses the effects of narcotics and synthetic analgesic:
-Central nervous system
-Respiratory depression
-Respiratory arrest

Question 5

Indications for naloxone

Answer 5

Narcotics:

• morphine (MSContin)
• heroin
• oxycodone (OxyContin)
• methadone
• codeine
• meperidine (Demerol)
• fentanyl (Sublimaze)
• hydrocondone (Vicodin)
• hydromorphone

Unconsciousness of unknown etiology

Question 6

Contraindications for naloxone

Answer 6

None in the emergency setting

Question 7

Adverse reactions for naloxone

Answer 7

Withdrawal symptoms:

• Confusion
• Hypotension
• Tachycardia
• Hypertension
• Dysrhythmias
• Diaphoresis
• Nausea
• Vomiting

Question 8

Routes of administration for naloxone

Answer 8

IV
IO
IM
ET
Intra-nasal (IN)

Question 9

Onset/Peak/Duration for naloxone (IV/IO)

Answer 9

O: < 2 minutes
P: < 2 minutes
D: 20 minutes - 2 hours

Question 10

Adult dosages for naloxone (IV/IO)

Answer 10

2 mg

May repeat the dose every 2 minutes

Question 11

Pediatric dosages for naloxone (IV/IO)

Answer 11

0.1 mg/kg (up to 2 mg per dose)

May repeat the dose every 2 minutes

Question 12

Onset/Peak/Duration for naloxone (IM/IN)

Answer 12

O: 2-10 minutes
P: 2-10 minutes
D: 20 minutes - 2 hours

Question 13

Adult dosages for naloxone (IN)

Answer 13

1 mg sprayed in each nostril with a mucosal atomizer device (MAD)
May repeat the dose every 2 minutes

Question 14

Pediatric dosages for naloxone (IN)

Answer 14

1 mg sprayed in each nostril with a mucosal atomizer device (MAD)
May repeat the dose every 2 minutes