midazolam

Question 1

Trade name for midazolam

Answer 1

Versed

Question 2

Classes for midazolam

Answer 2

Benzodiazepine
Anticonvulsant
Sedative
Hypnotic

Question 3

Standard supply for midazolam

Answer 3

Vial

Question 4

MOA for midazolam

Answer 4

Produces sedation by acting on the limbic system, the thalamus, and hypothalamus
Binds to gamma-amino acid (GABA) benzodiazepine receptors in the brain
Raises the seizure threshold
Produces tranquilizing (antianxiety) effect on the central nervous system

Question 5

Indications for midazolam

Answer 5

Seizure activity
Status epilepticus
Procedural sedation for intubation and cardioversion
Chemical restraint for agitated (excited) delirium

Question 6

Contraindications for midazolam

Answer 6

Known hypersensitivity

Question 7

Adverse reactions for midazolam

Answer 7

Sedation
Transient amnesia
Respiratory depression
Respiratory arrest
Bradycardia
Hypotension
Dizziness
Blurred vision
Nausea
Vomiting

Question 8

Routes of administration for midazolam

Answer 8

IV
IO
IM

Question 9

Adult dosages for midazolam (seizure)

Answer 9

IV/IO: 0.1 mg/kg
Max dosage: 4.0 mg

IM: 0.2 mg/kg
Max dosage: 10 mg

Question 10

Pediatric dosages for midazolam (seizure)

Answer 10

IV/IO: 0.05-0.1 mg/kg
IM: 0.2 mg/kg
Max dosage: 10 mg

Question 11

Special consideration for midazolam

Answer 11

Consider decreased dosages for elderly patients and patients with liver and kidney disease due to slower metabolic function

Question 12

Onset/Peak/Duration for midazolam (IV/IO)

Answer 12

O: 2-5 minutes
P: 3-5 minutes
D: < 2 hours

Question 13

Onset/Peak/Duration for midazolam (IM)

Answer 13

O: 15-20 minutes
P: 30-60 minutes
D: 1-6 hours

Question 14

Adult dosages for midazolam (sedation)

Answer 14

IV/IO: 0.5-2.5 mg

Max dosage: 0.1mg/kg

Question 15

Adult dosages for midazolam (restraint)

Answer 15

IV/IO: 0.05-0.1 mg/kg

IM: 0.1 -0.15 mg/kg

Question 16

Pediatric dosages for midazolam (sedation)

Answer 16

IV/IO: 0.05-0.5 mg/kg

Max dosage: 0.1 mg/kg