magnesium sulfate

Question 1

Classes for magnesium sulfate

Answer 1

Electrolyte
Anti-inflammatory
Tocolytic

Question 2

MOA for magnesium sulfate

Answer 2

Decreases ventricular irritability
Decreases release of acetylcholine
Causes uterine relaxation
Bronchodilation
Raises seizure threshold in eclampsia and preeclampsia

Question 3

Indications for magnesium sulfate

Answer 3

Seizures caused by toxicity of pregnancy
Pregnancy induced hypertension
Pre-term labor
Torsades de Pointes
V-fib and pulseless V-tach refractory to amiodarone or lidocaine
Reactive airway conditions

Question 4

Contraindications for magnesium sulfate

Answer 4

Hemodynamically significant heart block

Question 5

Adverse reactions to magnesium sulfate

Answer 5

CNS depression
Drowsiness
Hypotension
Respiratory depression
Dysrhythmias

Question 6

Routes of administration for magnesium sulfate

Answer 6

IV
IO
Infusion

Question 7

Onset/Peak/Duration magnesium sulfate

Answer 7

O: Immediate
P: Variable
D: 1 hour

Question 8

Adult dosages for magnesium sulfate (torsades de pointes)

Answer 8

1-2 Gm in 50-100 mL over 5 minutes

May repeat the dose (1-2 Gm) over 1 hour

Question 9

Pediatric dosages for magnesium sulfate

Answer 9

Reactive airway conditions infusion: 25-50 mg/kg 10% solution infused over 15-30 minutes
Max dose: 2 Gm

Question 10

Special considerations for magnesium sulfate

Answer 10

An infusion pump should be used to administer the drug when possible

Question 11

Standard supply for magnesium sulfate

Answer 11

Vial

Question 12

Adult dosages for magnesium sulfate (pre-term labor/pre-eclampsia/eclampsia)

Answer 12

3-6 Gm in 100 mL over 10-20 minutes

May repeat initial dose

Question 13

Adult dosages for magnesium sulfate (maintenance infusion)

Answer 13

1-4 Gm/hr

Question 14

Adult dosages for magnesium sulfate (cardiac arrest)

Answer 14

1-2 Gm over 1-2 minutes

Question 15

Adult dosages for magnesium sulfate (reactive airway diseases)

Answer 15

2 Gm in 50 mL over 5-10 minutes