lorazepam

Question 1

Trade name for lorazepam

Answer 1

Ativan

Question 2

Classes for lorazepam

Answer 2

Benzodiazepine
Anticonvulsant
Sedative
Hypnotic

Question 3

Standard supply for lorazepam

Answer 3

Vial

Question 4

MOA for lorazepam

Answer 4

Produces sedation by acting on the limbic system, the thalamus, and cortex
Binds to gamma-amino butyric acid (GABA) benzodiazepine receptors in the brain
Raises the seizure threshold
Produces tranquilizing (antianxiety) effect on the central nervous system

Question 5

Indications for lorazepam

Answer 5

Seizure activity
Status epilepticus
Procedural sedation for intubation and cardioversion
Chemical restraint for agitated (excited) delirium
Severe anxiety

Question 6

Contraindication for lorazepam

Answer 6

Known hypersensitivity

Question 7

Adverse reactions for lorazepam

Answer 7

Sedation
Transient amnesia
Respiratory depression
Respiratory arrest
Bradycardia
Hypotension
Dizziness
Blurred vision
Nausea
Vomiting

Question 8

Routes of administration for lorazepam

Answer 8

IV
IO
IM

Question 9

Onsets of actions for lorazepam

Answer 9

IV/IO: 1-5 minutes

IM: 15-30 minutes

Question 10

Adult dosages for lorazepam (seizure)

Answer 10

Seizure IV/IO: 2.0-5.0 mg over 2 minutes

Seizure IM: 2.0-5.0 mg

Question 11

Pediatric dosage for lorazepam

Answer 11

Seizure IV/IO/IM: 0.05-0.1 mg/kg over 2 min

Maximum dosage: 4.0 mg

Question 12

Special considerations for lorazepam

Answer 12

Drug may produce longer periods of sedation with elderly patients

Question 13

Onset/Peak/Duration for lorazepam (IV/IO)

Answer 13

O: 1-5 minutes
P: < 15 minutes
D: 6-8 hours

Question 14

Onset/Peak/Duration for lorazepam (IM)

Answer 14

O: 15-30 minutes
P: 2-3 hours
D: 6-8 hours

Question 15

Adult dosages for lorazepam (sedation)

Answer 15

IV/IO: 2 mg over 2 minutes

IM: 4 mg (10 mg MAX)