Muscular System Flashcards
muscle tissue is divided into 3 muscles:
- Skeletal Muscle
- Cardiac Muscle
- Smooth Muscle
____________ are attached to the skeletal system and allow us to move
Skeletal Muscle
6 Functions of Skeletal Muscles:
- Produce skeletal movement
- Maintain body position and posture
- Support soft tissues
- Guard body openings (entrance/exit)
- Maintain body temperature
- Store Nutrient reserves
Muscles have 3 layers of connective tissues:
- Epimysium
- Perimysium
- Endomysium
Epimysium
- Exterior collagen layer.
- Connected to the deep fascia
- epi - outside; mysium - muscle
Perimysium
- Surrounds muscle fiber bundles (fascicles).
- It contains blood vessels and nerve supply to fascicles
- peri - surround; mysium - muscle
Endomysium
- Surrounds individual muscle cells (muscle fibers)
- Contains capillaries and nerve fibers contracting muscle cells
- Contains satellite cells (stem cells) that repair damage
- endo - internal/inside; mysium - muscle
Skeletal muscle cells are called __________
Fibers
Muscles have extensive vascular systems that:
- supply large amounts of oxygen
- supply nutrients
- carry away wastes
Skeletal muscles are _________ muscles, controlled by ________ of the central nervous system
Voluntary
Nerves
Skeletal Muscle Fibers
- Are very long
- Develop through fusion of mesodermal cells (myoblasts- embryonic cells))
- Become very large
- Contain hundreds of nuclei –multinucleate
- Unfused cells are satellite cells- assist in repair after injury
The cell membrane of a muscle cell
Sarcolemma
sarcoplasm
cytoplasm of muscle fiber
- Transmit action potential – impulses through cell
- Allow entire muscle fiber to contract simultaneously
- Have same properties as sarcolemma
Filled with extracellular fluid
Transverse Tubules (T tubules)
Myofibrils
1-2um in diameter
* Lengthwise subdivisions within muscle fiber
* Made up of bundles of protein filaments
2 Types of Myofilaments:
- Thin filaments - made of the protein actin
- Thick filaments - made of the protein myosin
__________ are responsible for muscle contraction
Myofilaments
- A membranous structure surrounding each myofibril
- Helps transmit action potential to myofibril
- Similar in structure to smooth endoplasmic reticulum
- Forms chambers (terminal cisternae) attached to T tubules
Sarcoplasmic Reticulum (SR)
________ is formed by 1 T tubule and 2 terminal cisterna
Triad
Concentrate Ca2+ (via ion pumps)
Cisternae
The contractile units of muscle
Sarcomeres
the function of satellite cells
repair damage in the endomysium
the function of tendons
a flexible tissue that connects the muscles to the bones
the function of ligaments
fibrous connective tissue that attaches bone to bone
A striped or striated pattern within myofibrils: alternating dark, thick filaments (A bands) and light, thin filaments (I bands)
Muscle Striations
- the center of the A band
- at midline of sarcomere
M line
- the centers of the I bands
- at 2 ends of sarcomere
Z lines
The densest, darkest area on a light micrograph
Zone of Overlap
The area around the M line
H Zone
________ are strands of protein
Titin
_______ is caused by interactions of thick and thin filaments
Muscle Contraction
- is 2 twisted rows of globular G actin
- the active sites on G actin strands bind to myosin
F actin
holds F actin strands together
Nebulin
- is a double strand
- prevents actin-myosin interaction
Tropomyosin
a globular protein
Troponin
- Ca2+ binds to receptor on troponin molecule
- Troponin–tropomyosin complex changes
- Exposes active site of F actin
Initiating Contraction
- Contain twisted myosin subunits
- Contain titin strands that recoil after stretching
Thick Filament
The Mysosin Molecule
Tail:
binds to other myosin molecules
Head:
made of 2 globular protein subunits
reaches the nearest thin filament
During contraction, myosin heads:
- interact with actin filaments, forming cross-bridges
- pivot, producing motion
__________ is the location of neural stimulation
Neuromuscular Junction
- Releases neurotransmitter (acetylcholine or ACh)
- Into the synaptic cleft (gap between ______________ and motor end plate)
Synaptic Terminal
travels across the synaptic cleft
Acetylcholine or ACh
Generated by increase in sodium ions in sarcolemma
Action Potential
5 Steps of the Contraction Cycle
- Exposure of active sites
- Formation of cross-bridges
- Pivoting of myosin heads
- Detachment of cross-bridges
- Reactivation of myosin
As sarcomeres shorten, muscle pulls together, producing tension
Fiber Shortening
Contraction Duration depends on:
- duration of neural stimulus
- number of free calcium ions in sarcoplasm
- availability of ATP
- Ca2+ concentrations fall
- Ca2+ detaches from troponin
- Active sites are recovered by tropomyosin
- Sarcomeres remain contracted
Relaxation
A fixed muscular contraction after death
Rigor Mortis
Skeletal muscle fibers _________ as thin filaments slide between thick filaments
shorten