(continuation) Digestive System Flashcards
Cells of Gastric Glands:
- Regenerative cells
- Parietal cells
- Chief cells
- Enteroendocrine cells
divide rapidly to produce new cells that migrate to surface
Regenerative cells
secrete HCl acid and intrinsic factor
Parietal cells
secrete pepsinogen
Chief cells
secrete hormones and paracrine messengers
Enteroendocrine cells
Gastric Secretions:
- 2 to 3 L of gastric juice/day (H2O, HCl and pepsin)
- Parietal cells contain carbonic anhydrase (CAH)
Functions of Hydrochloric Acid:
- Activates pepsin and lingual lipase
- Breaks up connective tissues and plant cell walls
- Converts ingested ferric ions (Fe3+) to ferrous ions (Fe2+)
- Destroys ingested bacteria and pathogens
essential for B12 absorption by the small intestine. RBC production (lack causes pernicious anemia)
Intrinsic factor
secreted as pepsinogen (inactive). HCl converts it to pepsin (active)
Pepsin
lipase digests the butterfat of milk in infants. chymosin curdles milk by coagulating proteins
Gastric lipase and chymosin
hormones enter blood
distant cells
paracrine secretions
neighboring cells
signaling molecules produced in digestive tract and CNS
Gut-brain peptides
Swallowing center signals stomach to relax
Gastric Motility
when abdominal contraction forces upper esophageal sphincter to open
vomiting