More on adaptive immunity

Question 1

_____ lymphocytes of humoral immunity produce antibodies that bind to antigens and _____ them for destruction by other means

Answer 1

B; tags

Question 2

Recognition
- Immunocompetent B cell has _______ of surface receptors for one antigen
- Activation beings when an antigen binds to several of these receptors, links them together, and is taken _____ the cell by ___________________
- Small molecules are not antigenic because they cannot link multiple receptors together (_______)
- B-cell processes (________) the antigen
- Links some of these epitopes to its ________ proteins
-Displays these on the cell ___________

Answer 2

• thousands
• INTO; receptor-mediated endocytosis
• happens
• digests
• MHC-II
• surface

Question 3

Attack
- antibodies bind to antigen, render it harmless, “____ it” for _________

Memory
- Some ____ cells differentiate into __________ cells

Answer 3

• tag; destruction
• B; memory

Question 4

Clonal Selection and Ensuing Events of the Humoral Immune Response
1. ________ recognition
- immunocompetent B cells exposed to antigen…. binds only to B cells with complementary _________

2. Antigen ___________
   - B cells internalizes antigen and ________ processed _______. ________ T cell binds to B cell and secretes __________
3. _______ ___________
   - interleukin stimulates B cell to _________ repeatedly and form a _________
4. ______________
   - some cells of the clone become ________ B cells. _____ differentiate into ________ cells
5. ___________
   - ________ cells synthesize and secrete __________ which employ various means to render antigen harmless

Answer 4

1. Antigen
   - receptors
2. presentation
   - displays; epitope; interleukin
3. Clonal selection
   - divide; clone
4. Differentiation
   - memory; MOST; plasma
5. Attack
   - Plasma; antibody

Question 5

Plasma cells have a lot of ________ and ________ because they create __________ antibodies per second

Answer 5

rough ER; mitochondria
- 2,000

Question 6

Primary response (first exposure): antibody ______ is first produced and then _____ is produced at a little bit higher amount
Secondary response (re-exposure): antibody _____ is produced very fast in high amount compared to _____ against that pathogen

Answer 6

IgM; IgG

IgG; IgM