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MT2 > Lymphoid Organ and Cells of Immune System > Flashcards

Lymphoid Organ and Cells of Immune System Flashcards

1
Q

Primary lymphoid organs includes

A

Bone Marrow and Thymus

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2
Q

the site of B cells and T cell maturation.

A

Primary Lymphoid Organ: Bone Marrow and Thymus

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3
Q

Secondary lymphoid organ includes

A

Lymph Nodes, Tonsils, Appendix, Spleen, Peyer’s Patchers

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4
Q

It is the site of proliferation and differentiation of T cells and B cells.

A

Secondary lymphoid organ

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5
Q

Trapping site of pathogens, Production of
antibodies and site of phagocytosis.

A

Secondary lymphoid organ

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6
Q

Cells of immune system: innate immunity

A

Neutrophil
Eosinophil
Basophil
Mast Cell
Macrophage
Dendritic Cells

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7
Q

Polymorphonuclear leukocytes; respond to bacterial infection.

A

Neutrophil

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8
Q

Produce toxic proteins against certain parasites.

A

Eosinophil

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9
Q

Responds to allergic and hypersensitivity reactions.

A

Basophil

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10
Q

Tissue based basophil; binds with IgE.

A

Mast Cell

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11
Q

Precursor of monocyte; cells that migrate to the tissue; APC’s or Antigen Presenting Cell

A

Macrophage

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12
Q

Resemble the dendrites of nerve cells; APC’s

A

Dendritic cells

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13
Q

Cells that responds to bacterial infection.

A

Neutrophil

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14
Q

It is highly phagocytic and motile cells.

A

Neutrophil

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15
Q

Neutrophil is active in the ______ stage of infection.

A

initial

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16
Q

lobes of neutrophil

A

2 to 5 lobes

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17
Q

It has a phagocytic effect and have the ability
to leave the blood.

A

Eosinophil

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18
Q

eosinophil major role is to produce toxic proteins against parasites such as _______.

A

helminths

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19
Q

It releases substances such as histamine, that are important in inflammation and allergic response.

A

BASOPHIL and MAST CELL

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20
Q

Mast cells resembles _____ but larger
and more granules, it bind with ____.

A

basophils ; IgE

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21
Q

It has a major role in phagocytosis and antigen
presenting cells.

A

Macrophage

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22
Q

2 types of macrophage

A

Fixed
Wandering

23
Q

it is like a check post that will not allow the intruder to enter critical locations in the body.

A

Fixed Macrophage

24
Q

are roaming around connective tissue throughout the body.

A

Wandering Macrophage

25
Q

dendritic cells is believed to derived from _____

A

monocytes

26
Q
  • Covered with long membranous extensions.
  • Phagocytize antigen and present it to helper T lymphocytes.
  • Most potent phagocytic cell in the tissue.
A

DENDRITIC CELLS

27
Q

It kills extracellular organisms only.

A

Phagocytosis

28
Q

stages of phagocytosis

A
  1. Initiation Stage
  2. Chemotaxis
  3. Engulfment
  4. Digestion
  5. Excretion
29
Q

substances released by the cells

A

Cytokines

30
Q

cytokines includes

A
  1. Interleukins
  2. Interferon
  3. Tumor Necrosis Factor
  4. Chemokines
  5. Betalysin
  6. Complement
31
Q

an overall reaction of the body to injury or invasion by an infectious agent that is described by ________

A

Inflammation ; Aulus Cornelius Celsus

32
Q

functions of inflammation

A
  • To destroy injurious agent.
  • To limit the effects on the body by confining or walling off injurious agent and its by products.
  • To repair or replace tissue damaged by the injurious agent or by its product.
33
Q

cardinal signs of inflammation

A

i. Rubor: Redness
ii. Calor: Heat
iii. Dolor: Pain
iv. Tumor: Swelling
v. Functio Laesa: Loss of Function

34
Q

STAGES OCCUR IN INFLAMMATION

A
  1. Vascular Response
  2. Cellular Response
  3. Resolution and Repair
35
Q

Increased the blood supply and increased capillary permeability.

A

Vascular Response

36
Q

Migration of PMNs from the capillaries to the surrounding of tissues.

A

Cellular response

37
Q

Migration of macrophages to the injured sites.

A

Cellular response

38
Q

resolution and repair stage of inflammation is initiated by ________

A

fibroblast proliferation

39
Q

cells of immune system: adaptive immunity

A

T cells, B cells and Natural Killer Cells

40
Q

chief lymphocytes in blood and lymph.

A

T cells

41
Q

precursor cell in antibody production.

A

B cells

42
Q

it kills infected and malignant cells.

A

Natural Killer Cells

43
Q

Cells of Immune System: Adaptive Immunity
T cells subsets

A

CD4
CD8

44
Q

a t-cell subset that is a Helper cells or Inducer cells

A

CD4

45
Q

a t-cell subset that is a Suppressor or Cytotoxic cells

A

CD8

46
Q

T cells development

A
  1. Double Negative Thymocytes
  2. Double Positive Thymocytes
  3. Mature T cells
  4. Activated T cells
  5. Sensitized T cells
47
Q

B cells development

A
  1. Pro B Cells
  2. Pre B Cells
  3. Immature Cells
  4. Mature B Cells
  5. Activated B Cells
48
Q

B cell development with successful rearrangement of heavy chain genes

A

Pro B Cells

49
Q

B cell development with synthesis of the heavy chain part of the antibody molecule and surrogate light chain.

A

Pre B Cells

50
Q

Immature cells in B cell development is distinguished by the appearance of complete _____ molecules on the cell surface.

A

IgM

51
Q

Completion of light chain rearrangements commits (in what B cell development?)

A

Immature Cells

52
Q

In mature B cells (B cells development), ___ and ___ is present on the surface.

A

IgM and IgD

53
Q

Activated B Cells exhibit identifying markers that include _____ which is found on both activated T cells and B cells and act as a receptor for ______.

A

CD25 ; interleukin 2

54
Q

antibody production

A

Plasma Cells

MT2 (45 decks)

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