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MT2 > HEMA 2 - PLATELETS (function tests) > Flashcards

HEMA 2 - PLATELETS (function tests) Flashcards

1
Q

WHAT PLATELET FUNCTION TEST IS..

Aspects of platelet function test: In vivo screening test

Advantages: Physiological

Disadvantages: Insensitive, invasive and high inter-operator CV

A

Bleeding Time

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2
Q

WHAT PLATELET FUNCTION TEST IS..

Aspects of platelet function test: Responsive to panel of agonsists

Advantages: Diagnostic

Disadvantages: Labour intensive non-physiological

A

Aggregometry - turbidometric methods

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3
Q

WHAT PLATELET FUNCTION TEST IS..

Aspects of platelet function test: Responsive to panel of agonists

Advantages: Whole blood test

Disadvantages: Insensitive

A

Aggregometry - impedance methods

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4
Q

WHAT PLATELET FUNCTION TEST IS..

Aspects of platelet function test: Combined aggregation and ADP release

Advantages: More information

Disadvantages: Semi-quantitative

A

Aggregometry and luminescence

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5
Q

WHAT PLATELET FUNCTION TEST IS..

Aspects of platelet function test: Stored and released ADP

Advantages: Sensitive

Disadvantages: Specialised equipment

A

Adenine nucleotides

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6
Q

WHAT PLATELET FUNCTION TEST IS..

Aspects of platelet function test: Ultrastructural evaluation of platelets e.g dense granular defects or giant platelet disorders

Advantages: Diagnostic

Disadvantages: Specialised equipment

A

Electron Microscope

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7
Q

WHAT PLATELET FUNCTION TEST IS..

Aspects of platelet function test: Glycoprotein defects

Advantages: Simple

Disadvantages: Limited to major glycoproteins

A

Electrophoretic analysis

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8
Q

WHAT PLATELET FUNCTION TEST IS..

Aspects of platelet function test: Measures platelet interaction with fibrinogen/fibrin. Detects abnormalities in number, Gp IIb/IIIa, signalling and Fg.

Advantages: Simple

Disadvantages: Not specific

A

Clot retraction

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9
Q

WHAT PLATELET FUNCTION TEST IS..

Aspects of platelet function test: Global haemostasis

Advantages: Predicts bleeding

Disadvantages: Measures clot properties only, insensitive to aspirin

A

Thromboelastography (TEG)

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10
Q

WHAT PLATELET FUNCTION TEST IS..

Aspects of platelet function test: High shear platelet function

Advantages: Simple

Disadvantages: Requires blood counter

A

Glass filterometer

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11
Q

WHAT PLATELET FUNCTION TEST IS..

Aspects of platelet function test: In vivo platelet activation markers

Advantages: SImple, systemic measure of platelet activation

Disadvantages: Prone to artefact

A

Platelet release markers (e.g BTG PF4)

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12
Q

WHAT PLATELET FUNCTION TEST IS..

Aspects of platelet function test: Global haemostasis. High shear platelet function.

Advantages: Measures global haemostatic function

Disadvantages: Cost of cartridges

A

Clot signature analyser (CSA)

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13
Q

WHAT PLATELET FUNCTION TEST IS..

Aspects of platelet function test: High shear platelet adhesion/aggregation

Advantages: Small volume of blood, physiological

Disadvantages: Little widespread experience

A

Cone and plate(let) analyser (CPA) or IMPACT device

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14
Q

WHAT PLATELET FUNCTION TEST IS..

Aspects of platelet function test: Platelet glycoproteins, activation markers, platelet function

Advantages: Whole blood test, flexible, wide variety of tests

Disadvantages: Specialised operator expensive equipment

A

Flow Cytometry

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15
Q

WHAT PLATELET FUNCTION TEST IS..

Aspects of platelet function test: Platelet counting pre and post activation

Advantages: Simple point of care instruments

Disadvantages: indirect test measuring count after aggregation

A

Ichor - plateletworks

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16
Q

WHAT PLATELET FUNCTION TEST IS..

Aspects of platelet function test: Platelet contractile force, clot clastic modulus and thrombin generation time

Advantages: Rapid and simple

Disadvantages: Measure mainly clot properties

A

Hemostasis analysis system

17
Q

WHAT PLATELET FUNCTION TEST IS..

Aspects of platelet function test: Platelet procoagulant activity

Advantages: Simple

Disadvantages: Insensitive to aspirin and Gp Ib function

A

Hemostasus Device

18
Q

WHAT PLATELET FUNCTION TEST IS..

Aspects of platelet function test: Platelet micro-aggregates

Advantages: Sensitive, study hyperfunction

Disadvantages: Little wideaspread experience

A

Laser platelet aggregometer (PA-200)

19
Q

WHAT PLATELET FUNCTION TEST IS..

Aspects of platelet function test: High shear adhesion/aggregation

Advantages: Rapid and simple screening, In vitro bleeding time, potential point of care instrument

Disadvantages: Inflexible

A

Platelet function analyser (PFA-100)

20
Q

WHAT PLATELET FUNCTION TEST IS..

Aspects of platelet function test: Efficacy of anti-platelet therapy e.g Gp IIb/IIIa, aspirin, clopidogret

Advantages: Simple test point of care instrument

Disadvantages: Inflexible, cannot be used to detect platelet defects or VWD

A

Ultegra (RPFA) -rapid platelet function analyser

21
Q

WHAT PLATELET FUNCTION TEST IS..

Aspects of platelet function test: High shear platelet function

Advantages: Simple

Disadvantages: Little widespread experience

A

Thrombotic status analyser (TSA)

22
Q

WHAT PLATELET FUNCTION TEST IS..

Aspects of platelet function test: High shear platelet function and global haemostasis

Advantages: Simple

Disadvantages: Little widespread experience

A

Gorog Thrombosis Test

23
Q

WHAT PLATELET FUNCTION TEST IS..

Aspects of platelet function test: Platelet adhesion to a collagen membrane with a cut

Advantages: Simple

Disadvantages: Prototype

A

Platelet-Stat

24
Q

WHAT PLATELET FUNCTION TEST IS..

Aspects of platelet function test: Potentially measures total protein content

Advantages: Increasing sensitivity

Disadvantages: Normal proteome yet to be fully defines, loss of some membrane proteins during analysis. Requires pure preparations,

A

Sensitive proteomic analysis

25
Q

WHAT PLATELET FUNCTION TEST IS..

Aspects of platelet function test: measures total mRNA content by microarray technology

Advantages: Potentially measures message from all MK/platelet synthesized proteins

Disadvantages: Platelet genome yet to be fully defined. Required pure preparation. Instability of mRNA preparations.

A

Platelet Genome Analysis

MT2 (45 decks)

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