Leukemia

Question 1

4 types of leukemia?

Answer 1

ALL AML CML CLL

Question 2

What leukemias happen in midlife?

Answer 2

The M in AML and CML stands for midlife (actually myeloid, but pretend)

Age 55-65

Question 3

Leukemia in children?

Answer 3

ALL

Question 4

Leukemia in elderly?

Answer 4

CLL (chronic!)

Question 5

Kid with bone pain, anemia, frequent infection?

What do you see on smear?

Answer 5

ALL Abundant blasts

PAS and TdT positive

Question 6

What is Philadelphia chromasone?

Answer 6

t9;22

15% of adults ALL cases

Drug for it? imatinib

Question 7

Auer rods? Where do you see those? KNOW THIS!!

Answer 7

Rods in the cells. in AML

Question 8

What is a smudge cell?

Answer 8

CLL ruptured cell from slide prep b/c lymphocytes are ruptured

Question 9

Auer rods?

Answer 9

AML!

Question 10

What is blast crisis?

Answer 10

Mature myeloid cells to conversion immature blasts

In CML (looks like acute leukemia)

Question 11

What do you see in CML smear?

Answer 11

Increased myeloid procurers but no smudge!

Question 12

CML has what chromosome?

Answer 12

PHILE (while CreaM cheese ) 9;22. BCR ABL

tyrosine kinase always on

also rarely in ALL

Question 13

Myelodisplastic syndrome is what on slide? can become slides

Answer 13

looks like teddy roosevelt glasses. Neutrophils hypolobulated