Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

21 fall: histology > Lecture 8-10 lymphatics > Flashcards

Lecture 8-10 lymphatics Flashcards

1
Q

___ comprises the vessels and organs that allow the immune system to work

A

lymphatic system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

some components of the lymphatic system are

A

thymus, lymph nodes and spleen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

lymphatic system maintains ___

A

functional immunity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Primary lymphatic organs

A

bone marrow
thymus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Secondary lymphatic system

A

Lymph nodes
spleen
mucosa associated lymphoid tissue (MALT)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Tertiary Lymphatics

A

small lymphatics organs that show up during some diseases and preform immune functions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Adult cells of lymphatic system

A

effector B cells
effector T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

another name for effector B cells

A

plasma cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

where are lymphatic cells generated and “educated”

A

primary lymphoid organs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

where are lymphatic cells maintained and activated

A

secondary lymphoid organs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How do lymphatic cells survey an animal

A

Lymphocyte recirculation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

steps of innate immune response

A

first line of defense

rapid

mediated by non-specific effector cells (macrophages and neutrophils)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

steps of adaptive immune response

A

later, long lived, memory cells

mediated by T-cells and B cells (cellular-(T-cells) and humoral (B-Cells))

highly specific (antigen recognition)

requires initial innate immune response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

how does macrophages and neutrophils destroy pathogens

A

“eats them”

phagocytosis

innate immune response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

soluble proteins made by one cell that affect the function of another

A

cytokines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

chemotactic cytokines

A

chemokines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

explain how cytokines work

A

Macrophage eats pathogen, this triggers the release of cytokines, which will trigger dilation of local small blood vessels

adhesion molecules are expressed on inside of blood vessels.

these, adhesion molecules, attract leukocytes

leukocytes are taken out of the blood vessel and carried to the original infection because they are attracted by “chemokines”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

___ attracts more macrophages/neutrophils to help in the inflammatory response

A

chemokines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

what cells are requires for the initiating of adaptive immune response

A

dendritic cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

explain how dendritic cells work

A

capture some bacteria

breaks it up and then takes part of antigen and “presents” it on the dendritic cells surface

Then move to nearest lymphatic vessel and then “drains” into the nearest lymphatic organ (lymph node)

this activates T- Lymphocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

T cells and B cells have ___ on their surface

A

monoclonal antigen receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

small piece of pathogen that is recognized by T and B cell antigen receptors

A

antigen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Each B cell can identify many types of antigens

True or False

A

False

1 b cell=1 antigen

very specific

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Antigen presenting cells are also called ___

A

dendritic cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Where do T-cells develop

A

in the Thymus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

T cells can turn into

A

T-helper cells (CD4)
T-Cytotoxic (CD8)

(single positive SP)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

double positive T cells

A

precursor T cells that have CD4 and CD8

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

T-helper cells

A

CD4

producing cytokines and other soluble mediators that HELP other cells of the immune response including macrophages, eosinophils and B cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

T cytotoxic

A

CD8
finds and kills infected cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

How does T cell “see” antigen

A

antigen is expressed on surface of dendritic cell

T cell receptor (TCR) sees and binds to this peptide antigen

antigen is presented on specific MHC proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

MHC are found in what

A

dendritic cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

explain how pathogen gets expressed by dendritic cells

A

dentrictic cell eats pathogen

lysomes breaks down pathogen into antigen

MCH proteins are attached to antigen

this is then expressed onto membrane and is “seen” by the T cell receptor of a T cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

steps of T cell

A

recognition phase

activation phase (clonal expansion)

effector phase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

parts of effector phase of T cells

A

macrophage activation

B cell activation/antibody production

inflammation

memory T cells

T cell mediated Cytolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

B cells develop in the

A

bone marrow

Bursa of Fabricius (in chickens)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

what do B cells do

A

make antibodies

make memory cells (respond to second infection)

antigen receptor on surface is the antibody that Bcells will produce

BCR(antibody) only recognize 1 antigen (directly- free floating antigens)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

B cells turn into

A

activated -clonal expassion

memory cell or plasma cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

plasma cells are

A

B cells that have differentiated into plasma cells that have increased cytoplasm and increased ER that is used to make antibodies

antibody production

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

what do antibodies do?

A

neutralization (block viral binding)

agglutination (clumps together)

precipitation of dissolved antigens

these steps will be identified by macrophages and be eaten

activation of complement system

leads to

cell lysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

antibodies will activate the complement system which leads to

A

cell lysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

adaptive immunity is mediated by

A

B cells and T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

activated B cells make

A

antibodies (Humoral)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
43
Q

activated T cells make

A

cytokines/kills cells

(cellular)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
44
Q

unique antigen receptors

A

B cell receptors

T cell receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
45
Q

B cells recognize

A

“free” antigens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
46
Q

T cells recoginize

A

processed and MHC-presents antigen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
47
Q

Cytotoxic T cells

A

CD8

kill infected cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
48
Q

Helper T cells

A

CD4

help shape the specific immune response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
49
Q

primary lymphoid organs

A

where B cells and T cells develop

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
50
Q

B cells come from ___ and develop in ___

A

Fetal liver

bone marrow (pluripotent hematopoietic stem cells)

bone marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
51
Q

T cells come from ___ and mature in ____

A

fetal liver

bone marrow (pluripotent hematopoietic stem cells)

Thymus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
52
Q

Thymus

A

bilobed, mediastinal location anterior to the heart

stroma (support structure) is epithelial cells

lobes subdivided into lobules and are separated by trabeculae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
53
Q

the stroma of the thymus are

A

epithelial cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
54
Q

the lobules of the thymus are separated by

A

trabeculae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
55
Q

in mature animals the thymus

A

involutes and shrinks- not completely

humans early 20s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
56
Q

each lobule of the thymus are broken into two regions:

A

cortex -dark stained

medulla- lighter

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
57
Q

thymus is contained in ___

A

a capsule

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
58
Q

what is number 5

A

trabeculae that separate each lobule of the thymus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
59
Q

what is 3

A

medulla (inner lighter area) of the thymus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
60
Q

What is 2

A

Cortex (outer region -darker)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
61
Q

What is 4

A

capsule of the thymus, which covers the entire thymus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
62
Q

structure in thymus that is surrounded by cell death

A

hassal’s corpuscle

thymic corpuscle

found in medulla of lobule of thymus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
63
Q

developing T cells are called ___ and are found in ____

A

thymocytes (double negative (DN) cells CD4- CD8-)

found in cortex (outer darker region of thymus)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
64
Q

___ epithelial cells are found in the cortex of the thymus

A

cortical

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
65
Q

___ epithelial cells are found in the medulla of the thymus

A

medullary

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
66
Q

part of the thymus that are made from mesenchymal cells

A

capsule, trabeculae/septae containing blood vessels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
67
Q

___ are found in the medulla of the thymus

A

hassal’s corpuscles

dendritics cells

macrophages

68
Q

what might Hassal’s Corpuscles do

A

found in medulla of the thymus

keratinized epithelium, necrotic, possibly site of cell destruction??

69
Q

Thymocytes learn how to identify self from non self by ___

A

interacting

positive and negative selection of mature T cells

70
Q

errors in self recognition of T cells are

A

autoimmune diseases

71
Q

subcapsular cortex of thymus

A

immature T cell precursors (CD4-CD8- double negative cells) interact with cortical EC

begin to differentiate

T Cell receptor (TCR) proteins made and inserted into membrane (CD3+)

Cells obtain surface expression of CD4 and CD8 (double positive (DP) cells)

72
Q

mid cortex of thymus

A

TCR (T cell receptors) bind to self MHC on cortial epithelial cells (self recognition test)

thymocytes that recognize MHC get survival signal

Thymocytes that fail die or get eaten

Positive Selection

surviving thymocytes differentiate into CD4+ and CD8+ (single positive cells)

73
Q

TCR bind to self MHC on cortical epithelial cells

A

self recognition test

mid cortex of thymus

how to make a T Cell

74
Q

cell death

A

apoptosis

75
Q

steps of T cell development in the thymus

A
  1. double negative to double positive thymocytes
  2. positive selection (single positive cells)
  3. negative selection (self tolerance)
  4. exit
76
Q

if a thymocytes can not see a MHC the cell will

A

die

happens in mid-cortex

77
Q

negative selection of T cell development

A

step 3 happens in the corticomedullary junction

self tolerance test

dendritic cells and macrophages present common self antigens (parts of every part of the body)

self reactive T cells MHC die and get eaten (T cells see itself this is bad should not see itself as antigen)

NEGATIVE SELECTION

78
Q

Exit phase of T cell development

A

in the medulla of the thymus

mature T cells leave bis postcapillary venules to reach circulation

migrate to secondary lymph nodes to “meet” antigen

only around 2-5% make it to the end

79
Q

what % of thymocyes become mature T cells

A

2-5%

50,000,000 in and 1,000,000 out every day

80
Q

T cell precursors migrate from the ___ to the ___

A

bone marrow

thymus

81
Q

Thymus is a mesh of ___ and ___ epithelial cells

A

cortical

medullary

82
Q

Thymocytes differentiate and become ___ and ___

A

T Helper (CD4)

T Cytoxic (CD)

83
Q

Two tests that thymocytes undergo while in the thymus

A

positive (not self) selection

negative (self) selection

84
Q

B cell development happens in the ___, in neonatal pigs, sheep and cow, B cells can devlop in the ___ of the gut

A

bone marrow

Peyer’s Patches

85
Q

Describe B Cell development

A

happens in bone marrow (mammals)

B cells precursors interact with stromal cells that provide signals and growth factors promoting immunoglobin gene (antibody) rearrangment

self-reacting B cells die (negative selection) and surviving immature cells migrate via circulation to spleen and peripheral lymph nodes to fully mature (antibody class switch)

86
Q

B cells in birds

A

bursa of fabricius

round sac like diverticulum in the cloaca

many folds that have lymphoid follicles lined with pseudostratified columnar epithelium

cortex and medulla

anibody gene rearrangment/ conversion occurs in the cortex and negative selection leads to loss of self reactive B cells (lighter medulla)

87
Q

where and what is the bursa of fabricius

A

in birds need cloaca

where B cells develop

88
Q

Bursa of fabricius

NAME THE STRUCTURES

A
89
Q

B cells develop in the ___ of mammals and in some neonates in the ____

A

bone marrow

peyer’s patch

90
Q

B cells develop in the ___ in birds

A

bursa of fabricius

91
Q

self reactive B cells are ___

A

deleted, killed eaten

92
Q

examples of secondary lymphoid organs

A

lymph nodes (periphery)

spleen (blood)

Mucosa-associated lymphoid tissue (MALT)

Hemal Nodes (Ruminants)

93
Q

similarites of secondary lymphoid organs

A

discreet organs

segregated areas (zones)

B Cells in follicles

Germinal centers form in follicles when B cells activate/proliferate

T-cell area contains APCs(i.e. DCs)

lymphocytes (most) enter via blood

94
Q

differences in secondary lymphoid organs

A

architecture/structural components

mechanism of lymphocytes entry from blood

mechanism of antigen entry (from blood, lymphatics, via epithelium)

95
Q

secondary lymphoid organs are divided into two spaces

A

diffuse (T cells)

nodal (B Cells)

96
Q

T cells and ___ go to the same area of secondary lymphoid organs

A

dendritic cells (APCs)

97
Q

diffuse lymphatic tissue is where ___ go in secondary lymphoid organs

A

T cells and APCs (dendritic cells)

98
Q

nodular(follicles) areas of secondary lymphoid organs is where ___ go

A

B cells

99
Q

What do lymph nodes do

A

strategically placed to collect antigen from Tissues to be presented to lymphocytes

Antigens enter via lymphatic vessels (dendritic cells/fluid from tissues)

Most lymphocytes enter from blood-some T cells enter via lymphatics

fluid homeostatis

100
Q

Do avians have lymph nodes

A

NO

diffuse lymphatic tissue

lymphatic follicles/nodules

101
Q

explain lymphatic vessels

A

carry “lymph” from peripheral tissue to lymph nodes

blind ended one way vessels that begin in the interstitial space in tissues

102
Q

what is lymph

A

fluid inside lymphatic system that contains fluid, white blood cells (some T cells and dendritic cells) and antigens (free floating)

lymph comes from everywhere and drains through one way valves into lymph nodes

103
Q

lymphatic circulation

A

lymphatic capillary, lymphatic vessel, lymph node, lymphatic vessel, thoracic duct, subclavian vein….blood circulation

104
Q

describe lymphatic vessels

A

thin layer of endothelial cells

slow moving, not pumped

moved by negative intraluminal hydrostatic pressure that draws in fluid from the interstitial space of tissues (also SMC contractions/chemotaxis)

105
Q

Describe Lymph nodes

A

soft, pale tan oval- kidney shaped

buried in fat

swell when immune response ongoing

encased in a fibrous capsule with an internal framework of fibrous trabeculae/septae

interior is a mesh of reticular cells (stroma) and fibers containing highly segregated areas

106
Q

identify

A

lymph node

107
Q

T cell and dendritic cell areas of lymph node

A

paracortex (out part of lymph node) outside of follicles

3b

108
Q

What cells are found in the follicle of the lymph node

A

B cells

109
Q

antigens in dendritic cells (DCs) and fluid and some lymphcytes (<5%) enter via ___

A

afferent lymphatics

110
Q

Afferent lymphatic penetrate the capsule of the lymph node and drain into the

A

subcapsular sinus

111
Q

Lymph percolates through ___ to ___ then exits via ___ to throacic duct and back to blood circulation

A

paratrabecular sinuses(conduits) (cords)

medullary sinus

efferent lymphatics

112
Q

___ and ___ in sinuses of lymph node ___ antigen in lymph fuild

A

macrophages and DCs

phagocytose (eat)

113
Q

lymph in ____, lymph out ___

A

antigen rich

lymphocyte-rich

114
Q

paracortex of the lymph node has

A

T cells and dendritic cells

115
Q

B cell area of a lymphnode ___,has an inner area called ___ and outer area called ___

A

nodule

germinal center (primary, secondary, senescent)

corona

116
Q

FRCs

A

Fibroblastic Peticular Cells

attract T and DC cells

117
Q

FDCs

A

Follicular Dendritic cells

attract B cells

118
Q

FRCs and FDCs direct “zoning” by expressing

A

chemokines

Fibroblastic Reticular Cells -CCL19,CCL21

T cells and DC cells

Follicular Dendritic Cells- CXCL13

B Cells

119
Q

Fibroblastic Reticular Cells -

A

chemokine CCL19,CCL21

Chemokitic for T cells and Dendritic cells

(will bring T cells and DC together)

120
Q

Follicular Dendritic Cells

A

chemokine CXCL13

B cells are attracted to CXCL13

121
Q

Follicular Dendritic Cells are found in ___

A

follicles/nodules in lymph nodes (spleen and MALT)

122
Q

Explain Follicular Dendritic Cells

A

found in germinal centers(light zones) of the follicles/nodule of lymph nodes

Can see naked antigen or antibody with antigen attached and will capture it

Will release cytokine CXCL13 which will attract Bcell

BCell with the correct binding site will attach and will become

Plasma cell that makes antibodies

or

Memory B cell

123
Q

specialized post capillary venules in the paracortex through which lymphocytes (95%) and macrophages enter the lymph nodes

A

high endothelial venules

124
Q

why are HEV named that

A

High endothelial venules

the unusual plump and cuboidal morphology of the endothelial cells

125
Q

__ express lymphocyte-specific adhesion molecules

A

HEC

126
Q

After leaving via HEV, lymphocytes segregate into zones by following ___

A

chemokine gradients

127
Q

HEV are in the ___ of the lymph node

A

cortex

128
Q

lymph node what is the arrow?

A

HEV

high endothelial venules

129
Q

Medulla of the lymph node

A

inner part of lymph node (macrophages and plasma cells)

medullary sinus

medullary cords

130
Q

medullary sinus is lyphatic vessels separated by

A

medullary cords (reticular fibers)

131
Q

medullary sinus contains ___ that phagocytose debris/ microorganisms

A

macrophages

132
Q

Medullary cords contain ___ and __ that have migrated from germinal centers

A

macrophages

plasma cells

133
Q

Plasma cells make antibodies that exit the lymph node via ___ and enter circulation

A

efferent lymphatics

134
Q

Medullary sinus has ____

Medullary cord has ____

A

macrophages and reticular cells

packed with plasma cells

135
Q

The spleen

A

removed antigen directly from the blood to encounter B and T cells

removes and destroys aging red cells and other hematopoietic cells

during fetal development spleen can make blood cells, declines in adults but can reoccur in extreme anemia - extramedullary haematopoesis

136
Q

___ antigen and __ lymphocyte enter from the blood in the spleen

A

ALL and ALL

137
Q

during anemia or systemic infections, spleen can make lymphoid or red blood cells this is called

A

extramedullary haematopoesis

138
Q

parts of the spleen

A

white pulp- lymphocyte come here (antigen, T cells, B cells- where antigen recognition happens)

red pulp- where red blood cells go

sunuses

arterioles- found in

139
Q

red pulp of spleen

A

less cells/ red cell rich

site of. red cell destruction

network of splenic sinusoids

140
Q

white pulp of spleen

A

dense structures

contains lymphocytes

141
Q

PALS of spleen

A

periarteriolar lymphoid sheath

contain T cell Zone

area around the central arteriole

142
Q

Follicle of Spleen

A

Contains B cells (5% T helper)

143
Q

marginal zone of spleen

A

border of Red pulp and white pulp

contains M phages, DCs and B cells

144
Q

spleen

A
145
Q

blood circulation in the spleen

A

all antigens and lymphocytes enter from the blood

supplied only by arterial blood vis the trabecular artery

blood flows through central arteriole, the marginal sinus, arterioles, splenic sinuses, venules then to trabecular vein (closed circulation)

Lymphocytes and antigen also enter form terminal arterioles (Open circulation) into the red pulp

some arterioles/capillaries are sheathed in reticular fibers/macrophages (ellipsoids)

146
Q

marginal zone

A

lymphocytes migrate from blood to PALS (T cells) or the follicles (B cells)- driven by chemokines

antigens are eaten by macrophages, DCs and Marginal zone B cells in the “marginal zone”

macrophages, DCs and Marginal zone B cells carry antigen to T cells in PALS/Follicle that become activated and “help” B cells

antigen “presented” by Follicular Dendritic Cells to B cells in Follicles

147
Q

in the marginal zone of the spleen what eats antigens

A

macrophages, DCs and Marginal zone B cells

148
Q

MALT

A

mucosa-associated lymphoid tissue

collect antigen in mucosal surface:

respiratory tract

skin

intestinal tract

urogenital tract

mammary glands

149
Q

GALT

A

gut associated lymphoid tissue

150
Q

NALT

A

nasal associated lymphoid tissue

151
Q

MALT

unorganized

A

T cells (little dots) are scattered throughout the surface epithelial laters (inter-epithelial lymphocytes)

diffuse lymphatic tissue- not encapsulated

152
Q

organized MALT

A

tonsils in oral pharynx (lingual, tubal,palatine)

adenoids in nasal cavity

appendix in gut

Peyer’s patch in gut

153
Q

crypts are found in the palatine tonsil of ___

A

horses

no crypts in carnivores

154
Q

Horse Palatine Tonsil

A
155
Q

Where are peyer’s patches located

A

lower portion of the small intestine (distal jejunum and throughout the ileum)

156
Q

in pigs and ruminants what are the two types of peyer’s patches

A

jejunal patches: remain throughout life to protect intestine

ileocecal patches: early B cell development then regress (at 6 months)

157
Q

what is the largest collection of mucosal lymphoid tissue

A

peyer’s patch

158
Q

Dog Peyers Patch

A
159
Q

peyers patch provides ___ for gut

A

immune protection

160
Q

M Cells

A

multifold cells

help peyer’s patches in gut

highly specialized epithelial cells

sample antigens as they pass by (engulf antigens)

then bring the antigens into the prior patch

161
Q

how does salmonella get into body

A

uses M cells (multifold cells) to get into body

found in gut wall

162
Q

antigen in lumen is collected in specialized epithelial cells names Multifold cells that are within an area of ____

A

FAEs

follicle-associated epithelial cells

163
Q

antigens are brought from the gut, through the M cells, into the peyers patch by

A

transcytose

164
Q

lymphocytes enter peyers patch via

A

High Endothelial Venules (HEV) located in the T cell zones

165
Q

lymphocytes leave the peyers patch vis the

A

blood circulation

166
Q

Dendritic cells exit the peyers patch by

A

draining lymphatics- will migrate to mesenteric lymph nodes

21 fall: histology (36 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions