lab 9 lymph Flashcards
Clustered lymphatic nodules composing a Peyer’s patch are present in the lamina propria and/or submucosa at one side of the ___ .
Ileum
Germinal centers
some nodules have central pale areas due to the presence of lymphocytes with paler nuclei and larger amounts of cytoplasm.
The rim of small lymphocytes surrounding the germinal center is called the ___ or ___ of the nodule.
corona
marginal zone
Nodules in the Peyer’s patch are partly encapsulated by ___
ense irregular connective tissue.
Tonsils lie deep to the ____ that lines the oral cavity and pharynx.
stratified squamous epithelium
The surface over the tonsil may be smooth or it may form deep invaginations called ____
crypts
horse have crypts, carnivore do not
___ have crypts, carnivore do not
horse
___ are collections of nodules and diffuse lymphatic tissue in the sub-epithelial connective tissue.
tonsils
The entire tonsil of a dog, lies within a fossa, and is covered in part by a ____
semilunar fold
____ are extensions of the dense connective tissue of the capsule that dip into the interior
trabeculae
B cell areas
nodules
T cell areas
deep cortical lymphatic tissue
paracortex
densely cellular extensions of cortical tissue
medullary cords
Medullary ___ are crossed by many fine strands of pink cytoplasm representing the branches of reticular cells - the fibroblastic cells that form the meshwork in most lymphatic tissue.
sinuses
Macrophages often contain ____, a golden-brown pigment resulting from the breakdown of red blood cells.
hemosiderin
____ are peculiar lymphatic organs found in some species, especially in ruminants.
hemal nodes
Hemal nodes are similar in architecture to lymph nodes but are supplied with___
blood vessels
hemal nodes
ruminants.
similar to lymph nodes
supplied with blood vessels and lack lymphatic vessels.
encapsulated and have a subcapsular sinus.
Nodular and diffuse lymphatic tissue is surrounded by blood-filled communicating sinuses in a meshwork of cells that are probably smooth muscle cells.
In the spleen, ____ is blue/purple because it is composed of lymphocytes that take up hematoxylin
White pulp
in the spleen, Trabecular ___ have a distinct wall, whereas trabecular ___ are endothelial-line tunnels within the trabecular substance.
arteries
veins
In the horse, cat and dog, the capsule and trabeculae are largely composed of ___ cells which can relax and allow the spleen to fill with blood and contract and expel the stored blood back into the circulation.
smooth muscle
white pulp in the spleen is oriented around ___
central arteries
PALS
periarterial lymphatic sheaths
PALS is found where and what is inside
around the central arteries of the white pulp of the spleen
T cells and DC cells
the border of the white and red pulp of the spleen is called the
marginal zone
periarterial macrophage sheaths
ellipsoids
ellipsoids are found in the
marginal zone or red pulp of the spleen
___, these sheaths of macrophages form large pale nodules around red pulp arterioles that may be confused with cross sections of trabeculae.
ellipsoids (periarterial macrophage sheaths)
The thymus is surrounded by a thin capsule of connective tissue from which extend ___ that divide the gland into irregular ____
septa
lobules.
Each lobule has an outer more darkly stained area containing small lymphocytes called the ___ and an inner ____ containing fewer and larger lymphocytes.
cortex
medulla
pink laminated whorls of epithelial reticular cells in the medulla of the thymus
Hassal’s (thymic) corpuscles
why are there no nodules in the thymus?
nodules are for B cells. no B cells in thymus,
Thymus is where T cells grow up
saclike, oval, dorsal diverticulum of the wall of the proctodeum, a part of the bird’s cloaca.
Bursa of Fabricius,
The lumen of the Bursa of Fabricius is lined by ___
pseudostratified columnar epithelium.
Make up of Busra of Fabricius
lumen is lined by pseudostratified columnar epithelium.
Deep to the epithelium, thick layer of lymphatic tissue, divided into polyhedral lobules (follicles) by connective tissue septa.
Each lobule has a cortex and medulla.
The epithelium and underlying lymphatic tissue form folds that extend into the lumen of the bursa. As in the thymus, the meshwork supporting the lymphocytes in the bursa is formed by epithelial cells.
There is a capillary which separates the medulla from the cortex. It can be identified by the nucleated red blood cells within it.
In the Bursa of Fabricius, deep to the epithelium lies a thick layer of ___. This tissue is divided into ____ by connective tissue septa.
lymphatic tissue. polyhedral lobules (follicles)
In the Bursa of Fabricius, there is a ____ which separates the medulla from the cortex.
capillary
Birds do not have ____ but lymphatic nodules are scattered throughout and are especially frequent beneath the epithelium of the digestive and respiratory tracts.
lymph nodes
In birds, the thymus is similar to that in mammals but the ___ is different.
spleen
In birds, the distinction between___ and ___pulp is not as clear as in mammalian spleens
red and white
In birds, ____ is seen as irregularly shaped collections of lymphocytes in which there are several small arteries each bearing a small pink collar representing a periarterial reticular sheath.
White pulp
In bird spleens, ____ is very cellular (reticular cells, macrophages, lymphocytes and red blood cells); venous sinuses are also present in the red pulp. Several large arteries and veins can be seen but ___ are not present.
red pulp
trabeculae
In bird spleens, ____ is very cellular (reticular cells, macrophages, lymphocytes and red blood cells); venous sinuses are also present in the red pulp. Several large arteries and veins can be seen but ___ are not present.
red pulp
trabeculae
peyer’s patch
horse and dog tonsil
hemal node
spleen of cat
avian spleen
Peyer’s Patch
- Lymphatic nodule
- Germinal center
- Corona
- Diffuse lymphatic tissue
- Mucosa and the Peyer’s patches that extend into submucosa
- Ileal submucosa
- Muscularis externa
Equine Tonsil
- Stratified squamous epithelium
- Crypt
- Nodules
- Diffuse lymphatic tissue
- Mucous salivary gland
Palatine Tonsil
- Nodule
- Diffuse lymphatic tissue
- Mixed salivary glands
- Semilunar fold
Lymph node
- Dense connective tissue capsule
- Dense connective tissue trabeculae
- Cortex
3a. Cortical nodules with germinal centers
3b. Paracortex - Medulla
4a. Medullary cords
4b. Medullary sinus - Subcapsular sinus
lymph node cortex
- Paracortex
- Cortical nodules
- Germinal center within a cortical nodule
- Corona or marginal zone
- Subcapsular sinus
- Dense connective tissue capsule
Lymph node medulla
- Medullary cord
- Medullary sinus
- Blood vessels
Hemal Node
- Capsule
- Lymphatic nodule
- Diffuse lymphatic tissue
- Medullary sinus filled with blood
hemal node
- Capsule
- Cortex
- Medulla
- Nodule
- Diffuse lymphatic tissue
- Medullary sinus filled with blood
Contracted Spleen
- Capsule
- Red pulp
- White pulp
- Trabeculae
- Blood vessel within trabeculae
Spleen
- Red pulp
- White pulp
- Edge of the folicle
- Center of the folicle
- Central arteriole surrounded by the periarteriolar lymphatic sheath (PALS)
- Macrophage sheathed capillaries (ellipsoids)
- Marginal zone
Spleen
- Macrophage sheathed capillaries (ellipsoids)
- Red pulp
- Trabeculae
blood filled spleen
- Capsule
- Red pulp
- White pulp
- Trabeculae
Thymus
- Thymic lobule
- Cortex
- Medulla
- Capsule
- Trabeculae
Thymus
- Cortex
- Hassall’s corpuscle
- Medulla
Bursa of Fabricius
- Lumen
- Pseudostratified columnar epithelium
- Lobules (follicles)
- Muscularis
Bursa of Fabricius
- Lumen
- Pseudostratified columnar epithelium
- Lamina propria
- Medulla of lobule
- Cortex of lobule
- Epithelial tuft
Bursa of Fabricius
- Pseudostratified columnar epithelium
- Lamina propria
- Cortex of lobule
- Capillary filled with blood
- Undifferentiated epithelial cells
- Medulla of lobule
Avian Spleen
- Capsule
- White pulp
- Red pulp
- Artery
- Lymphatic nodules
avian spleen
- Red pulp
- White pulp
- Sheathed artery
peyer’s Patch
smooth muscle(pink border)
Dense Irregular Connective Tissue of Submucosa
Lymphatic Nodules In Submucosa
palatine tonsil of horse
secondary nodules
crypts
stratified squamous epithelium
hemal node of sheep
capsule
subcapsular sinus filled with blood
cortex
spleen
trabecula (capsule protruding in?)
blue area- white pulp (B and T cells)
spleen
trabecula
peyers patch
tonsil of dog
semilunar fold
hemal node
rumninants
hemal node
spleen
filled on top
not filled on bottom
part of the thymus
hassals corpuscle
thymus