Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pathology II > Lecture 6: Hemolymphatic system II > Flashcards

Lecture 6: Hemolymphatic system II Flashcards

1
Q

what are some examples of lymphoproliferative hematopoietic neoplasia

A
  1. Lymphoid leukemia
  2. Lymphoma
  3. Plasma cell tumors- plasmacytoma, multiple myeloma
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what are some myeloproliferative hematopoietic neoplasia

A

histiocytic, mast cell tumors, myeloid leukemia, myelodysplastic syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

where does lymphoid leukemia originate

A

Bone marrow—> blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

where does lymphoma originate

A

extramedullary origin—> tissue/organs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what is the most common hematopoietic malignancy in animals

A

lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what are the anatomical locations of lymphoma

A
  1. Cutaneous
  2. Multicentric- 2 or more organs
  3. Thymic
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what are the immunophenotypes of lymphoma

A

T cell and B cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what ultrasound or necropsy finding is typical of lymphoma

A

organomegaly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Do you have rengerative or non-regenerative anemia in lymphoma

A

non-regenerative

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what abnormal finding would be see on chemistry in lymphoma and why

A

hypercalcemic due to production of PTHrp by neoplastic cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

is T cell or B cell more common lymphoma type in cats

A

T cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

young cats or older cats: FeLV/retrovirus associated lymphoma

A

young cats

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

where do young cats typically get masses with FeLV associated lymphoma

A

thymic/mediastinal
Multicentric

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

where do older cats typically get lymphoma

A

gastrointestinal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Suspected T cell lymphoma in cats- where are the lesions and which one is more common in old vs young cats. Which ones are retroviral induced

A

left: thymic/mediastinal , young cat, retroviral
Middle: Multicentric, young cat, retroviral induced
Right: GI, older cat, not retroviral induced

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

is B or T cell lymphoma more common in dogs

A

B cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

what lesions do you see in dogs with B cell lymphoma

A

generalized lymph node enlargement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

from dog, based on these lesions what do you suspect

A

B cell lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

older or younger cattle: BLV associated (retroviral) induce lymphoma

A

older cattle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

what type of lymphoma do older cattle typically get

A

B cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

__% of cattle with BLV develop lymphoma

A

5%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

where are lesions of B cell lymphoma in cattle commonly found

A

abomasum, vertebral canal, heart, retrobulbar, uterus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

young cattle get what type of lymphoma

A

T cell lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

where are the lesions of T cell lymphoma in young cattle

A

thymus, Multicentric, cutaneous

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Lesions from cattle, owner informs you the cow is BLV positive. What is likely diagnosis

A

B cell lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

what type of lymphoma do horses get

A

B cell ( specifically T cell rich)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

what cells are activated B lymphocytes that produce antibodies

A

plasma cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

each plasma cell is only capable of producing ___of antibody directed towards one antigen

A

on specific type of clone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

If you have lots of monoclonal antibodies the source is likely ___

A

neoplastic plasma cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

if you detect polyclonal antibodies it is likely a response to ___

A

infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

T or F: plasmocytomas are usually malignant

A

false-benign

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

where are plasmocytomas found

A

cutaneous or MM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

what is likely dx

A

Plasmocytoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

what is multiple myeloma

A

malignant proliferation of plasma cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

what species is multiple myeloma most common in

A

dogs

36
Q

what is the origin of multiple myeloma

A

bone marrow, most commonly vertebrae

37
Q

2-3 of the following what 4 things must occur for dx of multiple myeloma

A
  1. Many plasma cells in bone marrow >30%
  2. Osteolysis
  3. Monoclonal gammopathy
  4. Light chain proteinuria
38
Q

necropsy and histo from dog who presented with severe back pain. What was likely cause

A

Multiple myeloma- many plasma cells and osteoblasts

39
Q

what are two common bloodwork finding associated with multiple myeloma

A

hyperglobulinemia- plasma cells making lots of antibodies
hypercalcemia: increase osteoclast activity

40
Q

T or F: histiocytic tumors are benign and focal

A

true

41
Q

what species commonly get histiocytic tumors

A

young dogs

42
Q

where are histiocytic tumors often located

A

head and extremities

43
Q

T or F: histiocytic tumors spontaneously regress

A

true

44
Q

young dog-what wrong

A

histiocytic tumor

45
Q

what is cutaneous reactive histiocytosis

A

Vasocentric proliferation of relatively benign looking macrophages (some lymphocytes)

46
Q

what is systemic reactive histiocytosis

A

identical vasocentric infiltrates found in LN, ocular and nasal mucosa, and internal organs

47
Q

what dog breed is predisposed to malignant histiocytic diseases

A

Bernese mountain dog

48
Q

what is wrong

A

Cutaneous reactive histiocytosis

49
Q

what are some gross findings histiocytic sarcoma

A

Nodular lesions in spleen, lung, LN

50
Q

what are some histo findings of histiocytic sarcoma

A

histiocytes are pleomorphic, multinucleated, atypical

51
Q

what are some gross findings of hemophagocytic subtype of histiocytic sarcoma

A

diffuse lesions on spleen

52
Q

what are some histo findings of hemophagocytic subtype of histiocytic sarcoma

A

infiltrates of atypical, pleomorphic histiocytes, erythrophagocytosis

53
Q

what wrong- what gross lesions and what histo show

A

Histiocytic sarcoma- nodules all over spleen

Histo: highly pleomorphic and multinucleated

54
Q

what wrong- what gross and histo show

A

Hemophagocytic subtype of histiocytic sarcoma

Gross: diffuse lesions on spleen

Histo: pleomorphic histiocytes, erythrophagocytosis

55
Q

Identify the two histiocytic proliferative disorders cats get based on these images

A

Left: feline progressive histiocytosis- skin nodules to plaques

Right: pulmonary histiocytosis

56
Q

what is the most common cause of uniform, bloody splenomegaly

A

barbiturate euthanasia

57
Q

what causes acute hyperemia of spleen

A

any bacterial septicemia (anthrax, salmonellosis)

58
Q

what causes acute hemolytic anemia

A

acute phagocytosis and sequestration

59
Q

what causes uniform, meaty splenomegaly

A

infiltration/proliferation of cells

60
Q

what are causes of these 3 hyperplastic spleens

A

Left: splenic lymphoid hyperplasia
2. Extramedullary hematopoiesis
3. Monocyte-macrophage hyperplasia

61
Q

what wrong

A

Granulomatous inflammation

62
Q

what wrong

A

Endocarditis leading to emboli causing infarcts in spleen

63
Q

what wrong and identify 1-2

A

Incomplete contraction
1. Congestion
2. Contraction

64
Q

what top differential, also found tumor on right auricle

A

Splenic hemagiosarcoma

65
Q

What wrong

A

Splenic hematoma

66
Q

what is the etiology of splenic siderotic plaques

A

result of healing of sites of previous trauma and hemorrhage, often incidentally in geriatric patients

67
Q

what these

A

Splenic siderotic plaques

68
Q

what this and what is sequela

A

nodular lymphoid hyperplasia

Can rupture—> hemoabdomen

69
Q

cheetah spleen, what is dx. Primary or secondary neoplasia

A

Myelolipomas

Primary neoplasia

70
Q

what wrong

A

splenic abscesses

71
Q

primary or metastatic neoplasia

A

metastatic

72
Q

What wrong

A

splenic granuloma

73
Q

what is the most common cause of a small spleen

A

contraction

74
Q

what occurs when you fracture/ rupture spleen

A
  1. +/- hemoabdomen
  2. +/- splenosis
75
Q

what is shown here

A

Splenosis- splenic parenchyma scattered on the peritoneum forming daughter spleens which may be functional

76
Q

what is the origin of thymoma

A

epithelial

77
Q

necropsy of old goat. Goat was also diagnosed with myasthenia gravis (or exfoliative dermatitis)- what is likely dx

A

thymoma

78
Q

T cell thymic lymphoma is viral associated in __ and spontaneous in __ (what species)

A

cat, cow

79
Q

what can cause the thymus to be too small

A

viral infection (parvo, distemper, FIV, FeLV), malnutrition, cachxeia, aging, chemotherapy, toxins, irradiation

80
Q

stress which increases release of ___lead to decrease thymic weight through apoptosis

A

glucocorticoids

81
Q

what viruses can cause thymus to be too small

A

canine parvo, canine distemper, FeLV, FIV, PRRSV, BVDV

82
Q

what wrong

A

Lymphoid hyperplasia

83
Q

what is inflammation of lymph node

A

lymphadentitis

84
Q

lymph node of dog, what wrong

A

Acute lymphadentitis- firm, hyperemic, swollen

85
Q

horse LN- what wrong and what could have caused

A

acute suppurative lymphadentitis

Cause: S. Equi/ strangles

86
Q

lymph node from goat who was recently sheared- what is likely cause

A

Caseous lymphadentitis due to corynebacterium pseudotuberculosis

87
Q

what wrong here and what are some diseases that can cause this

A

granulomatous lymphadentitis
Causes: cryptococcus (fungi), tuberculosis, Johne’s disease

Pathology II (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions