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Pathology II > Lecture 15: Liver pathology-II > Flashcards

Lecture 15: Liver pathology-II Flashcards

1
Q

What pattern do you expect with bacterial hepatitis

A

focal to multifocal random pale foci (embolic pattern)

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2
Q

how does bacteria gain entrance to liver

A
  1. Extension from bacterial peritonitis
  2. Biliary tree
  3. Hematogenous
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3
Q

bacterial or viral hepatitis

A

bacterial

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4
Q

what is the cause of Tyzzer’s disease (bacterial hepatitis)

A

clostridium piliforme

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5
Q

what are some predisposing factors to tyzzer’ diseases

A

high protein diet, stress/immunosuppression

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6
Q

what lesions are associated with tyzzer’s disease

A

multifocal necrosuppurative hepatitis

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7
Q

from foal- what likely dx and cause

A

tyzzer’s disease (bacterial hepatitis)
Cause: clostridium piliforme

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8
Q

what is cause of systemic leptospirosis (bacterial hepatitis)

A

leptospira interrogates

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9
Q

what are some signs of systemic leptospirosis (bacterial hepatitis)

A

icterus, signs of renal and hepatic disease, septicemia/shock

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10
Q

what are some gross findings of systemic leptospirosis (bacterial hepatitis)

A

ascites, hepatic necrosis, widespread hemorrhage, icterus

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11
Q

liver and gallbladder of cow- what is likely cause and dx

A

dx: hepatic salmonellosis
Cause: salmonella enterica stereotype Dublin

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12
Q

what is the most common cause of liver abscesses in ruminants

A

fusobacterium necrophorum

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13
Q

what is the gross appearance of viral hepatitis

A

small foci of hepatocellular necrosis, often with hemorrhage

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14
Q

what adenovirus causes viral hepatitis

A

Adenovirus I- infectious canine hepatitis

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15
Q

what herpesviruses cause viral hepatitis

A

BHV-1, EHV-1, CHV-1

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16
Q

from dog- what virus could’ve caused this presentation (look at gallbladder)

A

infectious canine hepatitis caused by adenovirus I

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17
Q

Viral or bacterial hepatitis

A

viral

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18
Q

what wrong

A

parasitic hepatitis
F. Hepatic lives in bile ducts—> fibrosis

19
Q

what wrong

A

Parasitic hepatitis
F. Magna migrates through liver parenchyma—> hepatic necrosis

20
Q

what clostridium causes “blacks disease” infectious necrotic hepatitis

A

C. Novyi type B

21
Q

What could’ve caused these “milk spotted” lesions on liver

A

parasite migration—> parasitic hepatitis

22
Q

what is the most common cause of chronic hepatitis in dogs

A

idiopathic- likely immune mediated

23
Q

chronic hepatitis often involves __accumulation in dogs

A

copper

24
Q

what breeds are predisposed to chronic hepatitis

A

Doberman pinschers, American and English cocker spaniels

25
Q

what is cirrhosis

A

chronic end stage liver disease

26
Q

what is the gross appearance of cirrhosis

A

regenerative nodules of hepatocytes surrounded by bands of fibrosis

27
Q

what are some consequences of cirrhosis

A
  1. Acquired PSS due to portal hypertension
  2. Hepatic insufficiency
28
Q

What wrong and likely pathogenesis

A

Ascites and cirrhosis
Pathogenesis: cirrhosis—> increased portal hypertension—> ascites

29
Q

what wrong

A

cirrhosis

30
Q

Wha are some therapeutic agents in dogs that can cause cirrhosis

A

Rimady/carprofen, phenobarbital

31
Q

what are some infectious causes of cirrhosis in dogs

A

leptospirosis

32
Q

what toxin can cause cirrhosis in dogs

A

copper

33
Q

horse liver- what wrong and likely cause

A

Cirrhosis due to plant toxins- pyrrolizidine alkaloid toxicity

34
Q

what this and who common in

A

nodular hyperplasia, common in old dogs

35
Q

what this

A

hepatocellular carcinoma

36
Q

What this

A

cholangiosarcoma

37
Q

From dog- metastatic or primary and what is top differential

A

metastatic hemangiosarcoma

38
Q

what is cholangitis

A

inflammation of bile duct

39
Q

what is cholecystitis

A

inflammation of gallbladder

40
Q

what is the consequence of gall bladder mucocles

A

rupture of gallbladder—> bile peritonitis

41
Q

What wrong

A

Cystic mucosal hyperplasia

42
Q

what this and what cause

A

gallbladder mucocele due to increased secretion of thick mucus by gallbladder epithelium—> obstruction or rupture

43
Q

what breed are gallbladder mucoceles common in

A

Shetland sheep dogs

44
Q

what other disorders are linked to gallbladder mucoceles

A

hyperadrenocorticism and hypothyroid

Pathology II (19 decks)

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