Lecture 15: Liver pathology-II Flashcards
What pattern do you expect with bacterial hepatitis
focal to multifocal random pale foci (embolic pattern)
how does bacteria gain entrance to liver
- Extension from bacterial peritonitis
- Biliary tree
- Hematogenous
bacterial or viral hepatitis
bacterial
what is the cause of Tyzzer’s disease (bacterial hepatitis)
clostridium piliforme
what are some predisposing factors to tyzzer’ diseases
high protein diet, stress/immunosuppression
what lesions are associated with tyzzer’s disease
multifocal necrosuppurative hepatitis
from foal- what likely dx and cause
tyzzer’s disease (bacterial hepatitis)
Cause: clostridium piliforme
what is cause of systemic leptospirosis (bacterial hepatitis)
leptospira interrogates
what are some signs of systemic leptospirosis (bacterial hepatitis)
icterus, signs of renal and hepatic disease, septicemia/shock
what are some gross findings of systemic leptospirosis (bacterial hepatitis)
ascites, hepatic necrosis, widespread hemorrhage, icterus
liver and gallbladder of cow- what is likely cause and dx
dx: hepatic salmonellosis
Cause: salmonella enterica stereotype Dublin
what is the most common cause of liver abscesses in ruminants
fusobacterium necrophorum
what is the gross appearance of viral hepatitis
small foci of hepatocellular necrosis, often with hemorrhage
what adenovirus causes viral hepatitis
Adenovirus I- infectious canine hepatitis
what herpesviruses cause viral hepatitis
BHV-1, EHV-1, CHV-1
from dog- what virus could’ve caused this presentation (look at gallbladder)
infectious canine hepatitis caused by adenovirus I
Viral or bacterial hepatitis
viral
what wrong
parasitic hepatitis
F. Hepatic lives in bile ducts—> fibrosis
what wrong
Parasitic hepatitis
F. Magna migrates through liver parenchyma—> hepatic necrosis
what clostridium causes “blacks disease” infectious necrotic hepatitis
C. Novyi type B
What could’ve caused these “milk spotted” lesions on liver
parasite migration—> parasitic hepatitis
what is the most common cause of chronic hepatitis in dogs
idiopathic- likely immune mediated
chronic hepatitis often involves __accumulation in dogs
copper
what breeds are predisposed to chronic hepatitis
Doberman pinschers, American and English cocker spaniels
what is cirrhosis
chronic end stage liver disease
what is the gross appearance of cirrhosis
regenerative nodules of hepatocytes surrounded by bands of fibrosis
what are some consequences of cirrhosis
- Acquired PSS due to portal hypertension
- Hepatic insufficiency
What wrong and likely pathogenesis
Ascites and cirrhosis
Pathogenesis: cirrhosis—> increased portal hypertension—> ascites
what wrong
cirrhosis
Wha are some therapeutic agents in dogs that can cause cirrhosis
Rimady/carprofen, phenobarbital
what are some infectious causes of cirrhosis in dogs
leptospirosis
what toxin can cause cirrhosis in dogs
copper
horse liver- what wrong and likely cause
Cirrhosis due to plant toxins- pyrrolizidine alkaloid toxicity
what this and who common in
nodular hyperplasia, common in old dogs
what this
hepatocellular carcinoma
What this
cholangiosarcoma
From dog- metastatic or primary and what is top differential
metastatic hemangiosarcoma
what is cholangitis
inflammation of bile duct
what is cholecystitis
inflammation of gallbladder
what is the consequence of gall bladder mucocles
rupture of gallbladder—> bile peritonitis
What wrong
Cystic mucosal hyperplasia
what this and what cause
gallbladder mucocele due to increased secretion of thick mucus by gallbladder epithelium—> obstruction or rupture
what breed are gallbladder mucoceles common in
Shetland sheep dogs
what other disorders are linked to gallbladder mucoceles
hyperadrenocorticism and hypothyroid
