Lecture 15: Liver pathology-II

Question 1

What pattern do you expect with bacterial hepatitis

Answer 1

focal to multifocal random pale foci (embolic pattern)

Question 2

how does bacteria gain entrance to liver

Answer 2

1. Extension from bacterial peritonitis
2. Biliary tree
3. Hematogenous

Question 3

bacterial or viral hepatitis

Answer 3

bacterial

Question 4

what is the cause of Tyzzer’s disease (bacterial hepatitis)

Answer 4

clostridium piliforme

Question 5

what are some predisposing factors to tyzzer’ diseases

Answer 5

high protein diet, stress/immunosuppression

Question 6

what lesions are associated with tyzzer’s disease

Answer 6

multifocal necrosuppurative hepatitis

Question 7

from foal- what likely dx and cause

Answer 7

tyzzer’s disease (bacterial hepatitis)
Cause: clostridium piliforme

Question 8

what is cause of systemic leptospirosis (bacterial hepatitis)

Answer 8

leptospira interrogates

Question 9

what are some signs of systemic leptospirosis (bacterial hepatitis)

Answer 9

icterus, signs of renal and hepatic disease, septicemia/shock

Question 10

what are some gross findings of systemic leptospirosis (bacterial hepatitis)

Answer 10

ascites, hepatic necrosis, widespread hemorrhage, icterus

Question 11

liver and gallbladder of cow- what is likely cause and dx

Answer 11

dx: hepatic salmonellosis
Cause: salmonella enterica stereotype Dublin

Question 12

what is the most common cause of liver abscesses in ruminants

Answer 12

fusobacterium necrophorum

Question 13

what is the gross appearance of viral hepatitis

Answer 13

small foci of hepatocellular necrosis, often with hemorrhage

Question 14

what adenovirus causes viral hepatitis

Answer 14

Adenovirus I- infectious canine hepatitis

Question 15

what herpesviruses cause viral hepatitis

Answer 15

BHV-1, EHV-1, CHV-1

Question 16

from dog- what virus could’ve caused this presentation (look at gallbladder)

Answer 16

infectious canine hepatitis caused by adenovirus I

Question 17

Viral or bacterial hepatitis

Answer 17

viral

Question 18

what wrong

Answer 18

parasitic hepatitis
F. Hepatic lives in bile ducts—> fibrosis

Question 19

what wrong

Answer 19

Parasitic hepatitis
F. Magna migrates through liver parenchyma—> hepatic necrosis

Question 20

what clostridium causes “blacks disease” infectious necrotic hepatitis

Answer 20

C. Novyi type B

Question 21

What could’ve caused these “milk spotted” lesions on liver

Answer 21

parasite migration—> parasitic hepatitis

Question 22

what is the most common cause of chronic hepatitis in dogs

Answer 22

idiopathic- likely immune mediated

Question 23

chronic hepatitis often involves __accumulation in dogs

Answer 23

copper

Question 24

what breeds are predisposed to chronic hepatitis

Answer 24

Doberman pinschers, American and English cocker spaniels

Question 25

what is cirrhosis

Answer 25

chronic end stage liver disease

Question 26

what is the gross appearance of cirrhosis

Answer 26

regenerative nodules of hepatocytes surrounded by bands of fibrosis

Question 27

what are some consequences of cirrhosis

Answer 27

1. Acquired PSS due to portal hypertension 2. Hepatic insufficiency

Question 28

What wrong and likely pathogenesis

Answer 28

Ascites and cirrhosis Pathogenesis: cirrhosis—> increased portal hypertension—> ascites

Question 29

what wrong

Answer 29

cirrhosis

Question 30

Wha are some therapeutic agents in dogs that can cause cirrhosis

Answer 30

Rimady/carprofen, phenobarbital

Question 31

what are some infectious causes of cirrhosis in dogs

Answer 31

leptospirosis

Question 32

what toxin can cause cirrhosis in dogs

Answer 32

copper

Question 33

horse liver- what wrong and likely cause

Answer 33

Cirrhosis due to plant toxins- pyrrolizidine alkaloid toxicity

Question 34

what this and who common in

Answer 34

nodular hyperplasia, common in old dogs

Question 35

what this

Answer 35

hepatocellular carcinoma

Question 36

What this

Answer 36

cholangiosarcoma

Question 37

From dog- metastatic or primary and what is top differential

Answer 37

metastatic hemangiosarcoma

Question 38

what is cholangitis

Answer 38

inflammation of bile duct

Question 39

what is cholecystitis

Answer 39

inflammation of gallbladder

Question 40

what is the consequence of gall bladder mucocles

Answer 40

rupture of gallbladder—> bile peritonitis

Question 41

What wrong

Answer 41

Cystic mucosal hyperplasia

Question 42

what this and what cause

Answer 42

gallbladder mucocele due to increased secretion of thick mucus by gallbladder epithelium—> obstruction or rupture

Question 43

what breed are gallbladder mucoceles common in

Answer 43

Shetland sheep dogs

Question 44

what other disorders are linked to gallbladder mucoceles

Answer 44

hyperadrenocorticism and hypothyroid