Lecture 4: integument part 3 Flashcards
what wrong
- Urticaria- hives, wheals: superficial dermis
- Angioedema: deep dermis/SQ
what type of hypersensitivity reactions are urticaria and angioedema
type 1 and 3
what type of hypersentivity reaction is atopic dermatitis
1 and 4
patients with atopic dermatitis are ___predisposed
genetically
what is pruritis
self-trauma, licking, rubbing external ears and paws
what Ig is present in atopic dermatitis
IgE
what secondary infections are common with atopic dermatitis
staphylococcus, malassezia
what wrong
atopic dermatitis
what type of hypersensitivity reactions are insect bite hypersensitivity
1 and 4
what type of hypersensitivity reaction are immunological skin diseases with gross vesicles/ bullae
type 2
if there are primary skin vesicles or bullae that have ancatholysis of desmosomes in intraepidermal clefts what is likely differential
pemphigus folliaceous
if there are primary skin vesicles or bullae that have ancatholysis of desmosomes in suprabasilar clefts what is likely differential
pemphigus vulgaris
if there are primary skin vesicles or bullae with basement membrane vesicles or bullae that have subbasilar clefts what is likely differential
bullous de matoses
what layer of skin is affected with pemphigus folliaceous
superficial epidermis
what is the target of autoantibodies in PF
desmoglein 1
in PF vesicles and pustules rupture for form__
secondary crusts, scales, alopecia, erosions
where are PF lesions located
nose, pinnae, periocular, paw pads, claw beds, coronary bands
what is the #1 autoimmune dz in horses
pemphigus folliaceous
what wrong
pemphigus folliaceous
what is the more severe form of pemphigus
pemphigus vulgaris
what is the target of autoantibodies for pemphigus vulgaris
desmoglein 3 and 1
what is desmoglein 3 involved in
adhesion of basal cells of epidermis and mucous membranes
what lesions are associated with PV
oral mucosa and cutaneous lesions of deep epidermis
In PV primary suprabasilar vesicles and pustules rupture to form ___
erosions and ulcerations
what are some signs of PV with oral lesions
hypersalivation, erosion, ulceration
Dog presents with oral ulcers, histo was taken- what is wrong
Pemphigus vulgaris
PV or PF
PF
what is the target of autoantibodies for bollous pemphigoid
hemidesmosomal proteins
In ballous pemphigoid primary subbasilar vesicles rupture to form __
secondary erosions, ulcerations, crusts
what wrong
bollous pemphigoid
PV, PF or bullous pemphigoid: separation of epidermis ad dermis
bollous pemphigoid
What dogs commonly get lupoid onychitis
large breeds, young adults to middle aged
how do dogs with lupoid onychitis present
claw sloughing then regrowth of misshapen claw
what is the pathology of lupoid onychitis
mononuclear inflammation targets nail bed epithelium—> dermo/ epidermal tearing and pigmentary in continence
what is needed in biopsy to dx lupoid onychitis
nailbed epithelium- can’t dz based on claw samples
Dog presents with sloughing off of claws, histo of nail bed what wrong
Lupoid onychitis
what is the cause of systemic lupus erythematous
immune dysregulation- autoantibodies and cytokine dysregulation
tissue injury in systemic lupus erythematous is due to
immune complex formation and deposition
antigen-antibody complexes of SLE binds in the skin __ and __
basement membrane and dermal vessels
what does the histo of SLE look like
interface lymphohistiocytic dermatitis with subepidermal vesicles, basal cell apoptosis, pigmentary incontinence
what infection would cause this in horse, what is wrong
purpura hemorrhagic, caused by S. Equi infection
what Does purpura hemorrhagic cause
immune complex vasculitis secondary to S. Equi
how does copper deficiency cause depigmentation
copper is needed to make tyrosinase enzyme which is needed to form tyrosine into melanin
5 week old pig, what wrong
porcine juvenile pustular psoriasiform dermatitis
T or F: porcine juvenile pustular psoriasiform dermatitis resolves spontaneously
true
what are some lesions associated with porcine juvenile pustular psoriasiform
symmetric coalescing pustules, papules, crusts on abdomen, going, medial thighs
what wrong with puppy
juvenile sterile granulomatous dermatitis and lymphadentitis (aka puppy strangles, juvenile cellulitis, juvenile pyoderma)
puppies < __ months typically infected with juvenile sterile granulomatous dermatitis and lymphadentitis
4 months
what is the form #1 of canine zinc responsive dermatosis
Siberian huskies and Alaskan malamutes with genetic predisposition to decreased intestinal absorption of zinc
what is the gross appearance of form #1 canine zinc responsive dermatosis
scale and crusts perioral, chin, periocular, ear, pressure points, paw pads
what is form #2 of canine zinc responsive dermatosis
rapidly growing large breed puppies with diet low in zinc or high in Ca2+ or phytates
what is the gross appearance of form #2 canine zinc responsive dermatosis
scale and plaques on skin in areas of repeated trauma
what histo appearance is consistent with form 1 and 2 canine zinc responsive dermatosis
parakeratosis with lymphocytic to eosinophilic perivascular dermatitis
zinc plays a key role in the formation of ___
structural protein during keratinization
husky presents with these lesions what is likely wrong
form #1 canine zinc responsive dermatosis
what lesions are consistent with endocrine alopecia in dogs
no pruritis, +/- symmetric alopecia, normal to atrophic epidermis/adnexa, hyperkeratosis, follicular dilation (comedoms/black heads), hyperpigmentation, lack of hair shafts/ increased telogen
what type of alopecia would be present with hypothyroidism
hair follicle is target, alopecia develops in areas of wear
what type of endocrine alopecia would spare head and limbs, cause calcinosis cutis and atrophy
hyperadrenocorticism
what kind of endocrine alopecia would be seen with hyper estrogen is
symmetric alopecia, no skin lesions
what type of endocrine alopecia would be seen with hypersomatotropism
thickened dermis, myxedema, thick/hard claws
what type of endocrine alopecia would be seen with hyposomatotropism
failure to grow and retention of puppy coat
cat paw, what wrong
plasma cell pododermatitis
what would biopsy of plasma cell pododermatitis show
plasma cells and Mott cells
acanthosis nigricans is common in what breeds
young dachshunds
lethal acrodermatitis is common in what breed
bull terriers
comedome syndrome is common in what breed
schanuzers
which is more common: primary or secondary neoplasia of the skin
primary
what this and is it likely primary or secondary neoplasia
lung digit syndrome, secondary (metastasized from lung)
