Lecture 4: integument part 3 Flashcards by Jen McGann

what wrong

Urticaria- hives, wheals: superficial dermis
Angioedema: deep dermis/SQ

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what type of hypersensitivity reactions are urticaria and angioedema

type 1 and 3

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what type of hypersentivity reaction is atopic dermatitis

1 and 4

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patients with atopic dermatitis are ___predisposed

genetically

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what is pruritis

self-trauma, licking, rubbing external ears and paws

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what Ig is present in atopic dermatitis

IgE

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what secondary infections are common with atopic dermatitis

staphylococcus, malassezia

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what wrong

atopic dermatitis

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what type of hypersensitivity reactions are insect bite hypersensitivity

1 and 4

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what type of hypersensitivity reaction are immunological skin diseases with gross vesicles/ bullae

type 2

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if there are primary skin vesicles or bullae that have ancatholysis of desmosomes in intraepidermal clefts what is likely differential

pemphigus folliaceous

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if there are primary skin vesicles or bullae that have ancatholysis of desmosomes in suprabasilar clefts what is likely differential

pemphigus vulgaris

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if there are primary skin vesicles or bullae with basement membrane vesicles or bullae that have subbasilar clefts what is likely differential

bullous de matoses

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what layer of skin is affected with pemphigus folliaceous

superficial epidermis

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what is the target of autoantibodies in PF

desmoglein 1

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in PF vesicles and pustules rupture for form__

secondary crusts, scales, alopecia, erosions

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where are PF lesions located

nose, pinnae, periocular, paw pads, claw beds, coronary bands

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what is the #1 autoimmune dz in horses

pemphigus folliaceous

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what wrong

pemphigus folliaceous

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what is the more severe form of pemphigus

pemphigus vulgaris

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what is the target of autoantibodies for pemphigus vulgaris

desmoglein 3 and 1

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what is desmoglein 3 involved in

adhesion of basal cells of epidermis and mucous membranes

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what lesions are associated with PV

oral mucosa and cutaneous lesions of deep epidermis

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In PV primary suprabasilar vesicles and pustules rupture to form ___

erosions and ulcerations

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what are some signs of PV with oral lesions

hypersalivation, erosion, ulceration

Dog presents with oral ulcers, histo was taken- what is wrong

Pemphigus vulgaris

PV or PF

what is the target of autoantibodies for bollous pemphigoid

hemidesmosomal proteins

In ballous pemphigoid primary subbasilar vesicles rupture to form __

secondary erosions, ulcerations, crusts

what wrong

bollous pemphigoid

PV, PF or bullous pemphigoid: separation of epidermis ad dermis

bollous pemphigoid

What dogs commonly get lupoid onychitis

large breeds, young adults to middle aged

how do dogs with lupoid onychitis present

claw sloughing then regrowth of misshapen claw

what is the pathology of lupoid onychitis

mononuclear inflammation targets nail bed epithelium—> dermo/ epidermal tearing and pigmentary in continence

what is needed in biopsy to dx lupoid onychitis

nailbed epithelium- can’t dz based on claw samples

Dog presents with sloughing off of claws, histo of nail bed what wrong

Lupoid onychitis

what is the cause of systemic lupus erythematous

immune dysregulation- autoantibodies and cytokine dysregulation

tissue injury in systemic lupus erythematous is due to

immune complex formation and deposition

antigen-antibody complexes of SLE binds in the skin __ and __

basement membrane and dermal vessels

what does the histo of SLE look like

interface lymphohistiocytic dermatitis with subepidermal vesicles, basal cell apoptosis, pigmentary incontinence

what infection would cause this in horse, what is wrong

purpura hemorrhagic, caused by S. Equi infection

what Does purpura hemorrhagic cause

immune complex vasculitis secondary to S. Equi

how does copper deficiency cause depigmentation

copper is needed to make tyrosinase enzyme which is needed to form tyrosine into melanin

5 week old pig, what wrong

porcine juvenile pustular psoriasiform dermatitis

T or F: porcine juvenile pustular psoriasiform dermatitis resolves spontaneously

true

what are some lesions associated with porcine juvenile pustular psoriasiform

symmetric coalescing pustules, papules, crusts on abdomen, going, medial thighs

what wrong with puppy

juvenile sterile granulomatous dermatitis and lymphadentitis (aka puppy strangles, juvenile cellulitis, juvenile pyoderma)

puppies < __ months typically infected with juvenile sterile granulomatous dermatitis and lymphadentitis

4 months

what is the form #1 of canine zinc responsive dermatosis

Siberian huskies and Alaskan malamutes with genetic predisposition to decreased intestinal absorption of zinc

what is the gross appearance of form #1 canine zinc responsive dermatosis

scale and crusts perioral, chin, periocular, ear, pressure points, paw pads

what is form #2 of canine zinc responsive dermatosis

rapidly growing large breed puppies with diet low in zinc or high in Ca2+ or phytates

what is the gross appearance of form #2 canine zinc responsive dermatosis

scale and plaques on skin in areas of repeated trauma

what histo appearance is consistent with form 1 and 2 canine zinc responsive dermatosis

parakeratosis with lymphocytic to eosinophilic perivascular dermatitis

zinc plays a key role in the formation of ___

structural protein during keratinization

husky presents with these lesions what is likely wrong

form #1 canine zinc responsive dermatosis

what lesions are consistent with endocrine alopecia in dogs

no pruritis, +/- symmetric alopecia, normal to atrophic epidermis/adnexa, hyperkeratosis, follicular dilation (comedoms/black heads), hyperpigmentation, lack of hair shafts/ increased telogen

what type of alopecia would be present with hypothyroidism

hair follicle is target, alopecia develops in areas of wear

what type of endocrine alopecia would spare head and limbs, cause calcinosis cutis and atrophy

hyperadrenocorticism

what kind of endocrine alopecia would be seen with hyper estrogen is

symmetric alopecia, no skin lesions

what type of endocrine alopecia would be seen with hypersomatotropism

thickened dermis, myxedema, thick/hard claws

what type of endocrine alopecia would be seen with hyposomatotropism

failure to grow and retention of puppy coat

cat paw, what wrong

plasma cell pododermatitis

what would biopsy of plasma cell pododermatitis show

plasma cells and Mott cells

acanthosis nigricans is common in what breeds

young dachshunds

lethal acrodermatitis is common in what breed

bull terriers

comedome syndrome is common in what breed

schanuzers

which is more common: primary or secondary neoplasia of the skin

primary

what this and is it likely primary or secondary neoplasia

lung digit syndrome, secondary (metastasized from lung)