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Pathology II > Lecture 4: integument part 3 > Flashcards

Lecture 4: integument part 3 Flashcards

1
Q

what wrong

A
  1. Urticaria- hives, wheals: superficial dermis
  2. Angioedema: deep dermis/SQ
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2
Q

what type of hypersensitivity reactions are urticaria and angioedema

A

type 1 and 3

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3
Q

what type of hypersentivity reaction is atopic dermatitis

A

1 and 4

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4
Q

patients with atopic dermatitis are ___predisposed

A

genetically

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5
Q

what is pruritis

A

self-trauma, licking, rubbing external ears and paws

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6
Q

what Ig is present in atopic dermatitis

A

IgE

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7
Q

what secondary infections are common with atopic dermatitis

A

staphylococcus, malassezia

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8
Q

what wrong

A

atopic dermatitis

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9
Q

what type of hypersensitivity reactions are insect bite hypersensitivity

A

1 and 4

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10
Q

what type of hypersensitivity reaction are immunological skin diseases with gross vesicles/ bullae

A

type 2

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11
Q

if there are primary skin vesicles or bullae that have ancatholysis of desmosomes in intraepidermal clefts what is likely differential

A

pemphigus folliaceous

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12
Q

if there are primary skin vesicles or bullae that have ancatholysis of desmosomes in suprabasilar clefts what is likely differential

A

pemphigus vulgaris

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13
Q

if there are primary skin vesicles or bullae with basement membrane vesicles or bullae that have subbasilar clefts what is likely differential

A

bullous de matoses

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14
Q

what layer of skin is affected with pemphigus folliaceous

A

superficial epidermis

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15
Q

what is the target of autoantibodies in PF

A

desmoglein 1

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16
Q

in PF vesicles and pustules rupture for form__

A

secondary crusts, scales, alopecia, erosions

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17
Q

where are PF lesions located

A

nose, pinnae, periocular, paw pads, claw beds, coronary bands

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18
Q

what is the #1 autoimmune dz in horses

A

pemphigus folliaceous

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19
Q

what wrong

A

pemphigus folliaceous

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20
Q

what is the more severe form of pemphigus

A

pemphigus vulgaris

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21
Q

what is the target of autoantibodies for pemphigus vulgaris

A

desmoglein 3 and 1

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22
Q

what is desmoglein 3 involved in

A

adhesion of basal cells of epidermis and mucous membranes

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23
Q

what lesions are associated with PV

A

oral mucosa and cutaneous lesions of deep epidermis

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24
Q

In PV primary suprabasilar vesicles and pustules rupture to form ___

A

erosions and ulcerations

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25
Q

what are some signs of PV with oral lesions

A

hypersalivation, erosion, ulceration

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26
Q

Dog presents with oral ulcers, histo was taken- what is wrong

A

Pemphigus vulgaris

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27
Q

PV or PF

A

PF

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28
Q

what is the target of autoantibodies for bollous pemphigoid

A

hemidesmosomal proteins

29
Q

In ballous pemphigoid primary subbasilar vesicles rupture to form __

A

secondary erosions, ulcerations, crusts

30
Q

what wrong

A

bollous pemphigoid

31
Q

PV, PF or bullous pemphigoid: separation of epidermis ad dermis

A

bollous pemphigoid

32
Q

What dogs commonly get lupoid onychitis

A

large breeds, young adults to middle aged

33
Q

how do dogs with lupoid onychitis present

A

claw sloughing then regrowth of misshapen claw

34
Q

what is the pathology of lupoid onychitis

A

mononuclear inflammation targets nail bed epithelium—> dermo/ epidermal tearing and pigmentary in continence

35
Q

what is needed in biopsy to dx lupoid onychitis

A

nailbed epithelium- can’t dz based on claw samples

36
Q

Dog presents with sloughing off of claws, histo of nail bed what wrong

A

Lupoid onychitis

37
Q

what is the cause of systemic lupus erythematous

A

immune dysregulation- autoantibodies and cytokine dysregulation

38
Q

tissue injury in systemic lupus erythematous is due to

A

immune complex formation and deposition

39
Q

antigen-antibody complexes of SLE binds in the skin __ and __

A

basement membrane and dermal vessels

40
Q

what does the histo of SLE look like

A

interface lymphohistiocytic dermatitis with subepidermal vesicles, basal cell apoptosis, pigmentary incontinence

41
Q

what infection would cause this in horse, what is wrong

A

purpura hemorrhagic, caused by S. Equi infection

42
Q

what Does purpura hemorrhagic cause

A

immune complex vasculitis secondary to S. Equi

43
Q

how does copper deficiency cause depigmentation

A

copper is needed to make tyrosinase enzyme which is needed to form tyrosine into melanin

44
Q

5 week old pig, what wrong

A

porcine juvenile pustular psoriasiform dermatitis

45
Q

T or F: porcine juvenile pustular psoriasiform dermatitis resolves spontaneously

A

true

46
Q

what are some lesions associated with porcine juvenile pustular psoriasiform

A

symmetric coalescing pustules, papules, crusts on abdomen, going, medial thighs

47
Q

what wrong with puppy

A

juvenile sterile granulomatous dermatitis and lymphadentitis (aka puppy strangles, juvenile cellulitis, juvenile pyoderma)

48
Q

puppies < __ months typically infected with juvenile sterile granulomatous dermatitis and lymphadentitis

A

4 months

49
Q

what is the form #1 of canine zinc responsive dermatosis

A

Siberian huskies and Alaskan malamutes with genetic predisposition to decreased intestinal absorption of zinc

50
Q

what is the gross appearance of form #1 canine zinc responsive dermatosis

A

scale and crusts perioral, chin, periocular, ear, pressure points, paw pads

51
Q

what is form #2 of canine zinc responsive dermatosis

A

rapidly growing large breed puppies with diet low in zinc or high in Ca2+ or phytates

52
Q

what is the gross appearance of form #2 canine zinc responsive dermatosis

A

scale and plaques on skin in areas of repeated trauma

53
Q

what histo appearance is consistent with form 1 and 2 canine zinc responsive dermatosis

A

parakeratosis with lymphocytic to eosinophilic perivascular dermatitis

54
Q

zinc plays a key role in the formation of ___

A

structural protein during keratinization

55
Q

husky presents with these lesions what is likely wrong

A

form #1 canine zinc responsive dermatosis

56
Q

what lesions are consistent with endocrine alopecia in dogs

A

no pruritis, +/- symmetric alopecia, normal to atrophic epidermis/adnexa, hyperkeratosis, follicular dilation (comedoms/black heads), hyperpigmentation, lack of hair shafts/ increased telogen

57
Q

what type of alopecia would be present with hypothyroidism

A

hair follicle is target, alopecia develops in areas of wear

58
Q

what type of endocrine alopecia would spare head and limbs, cause calcinosis cutis and atrophy

A

hyperadrenocorticism

59
Q

what kind of endocrine alopecia would be seen with hyper estrogen is

A

symmetric alopecia, no skin lesions

60
Q

what type of endocrine alopecia would be seen with hypersomatotropism

A

thickened dermis, myxedema, thick/hard claws

61
Q

what type of endocrine alopecia would be seen with hyposomatotropism

A

failure to grow and retention of puppy coat

62
Q

cat paw, what wrong

A

plasma cell pododermatitis

63
Q

what would biopsy of plasma cell pododermatitis show

A

plasma cells and Mott cells

64
Q

acanthosis nigricans is common in what breeds

A

young dachshunds

65
Q

lethal acrodermatitis is common in what breed

A

bull terriers

66
Q

comedome syndrome is common in what breed

A

schanuzers

67
Q

which is more common: primary or secondary neoplasia of the skin

A

primary

68
Q

what this and is it likely primary or secondary neoplasia

A

lung digit syndrome, secondary (metastasized from lung)

Pathology II (8 decks)

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