Lecture 5: Hemolymphatic system I Flashcards
Erythroid and myeloid precursors form what
erythroid: RBC
Myeloid: all other WBC
megakaryocytes form what
platelets
___cells are one precursor cell in bone marrow that gives rise to many different cell types
pluripotent hematopoietic stem cells
what is the role of erythropoietin
produce more RBC. It is produced by kidney and senses low blood volume or hypoxia and increases RBC
what does thrombopoitein do
increase platelet volume
which bone marrow is indicative of young vs old animal
red marrow- young
Yellow/fat marrow- old
what is extramedullary hematopoiesis
hematopoiesis occurring outside of the bone marrow
when does extramedullary hematopoiesis occur
during stress or disease states
What organ is responsible for filtering the blood
spleen
what is the red pulp
monocyte-macrophage system cells, vascular spaces, stromal cells, hematopoiesis
what is the white pulp
primary site for B and T cell interactions
what is the function of the trabecular smooth muscle in spleen
allows it to contract
what tissue is this and identify 1-2
spleen
1. White pulp
2. Red pulp
what is the structure and function of lymph node cortex
outer and inner, B and T cell follicles, respectively.
Important site for B/T cell interactions
what cells make up medulla of LN
cords of macrophages, lymphocytes, plasma cells and sinuses
lymph nodes ___specific areas of the body that allow for surveillance for ___within blood/lymph
drain, antigens
lymph h node- identify 1-6 (2, 4, and 6- what cells present)
- Outer cortex
- B cell follicles
- Inner cortex
- T cell follicles
- Medulla
- Macrophages, lymphocytes, plasma cells
where is the thymus located
cranial mediastinum
what is the purpose of the lymphoid portion of thymus
T lymphocyte development
what is function of epithelial portion of thymus and what does it contain
“scaffold for thymus”, Hassalls corpuscles
what type of tissue is this and identify 1-2
thymus
1. Lymphoid portion- t lymphocytes
2. Epithelial portion- hassall’s corpuscles
what is this structure in a young animal
thymus
what is the function of the thymus
differentiation and maturation of T lymphocytes, positive and negative selection
what is positive selection in thymus
survival of T lymphocytes because they appropriately recognize MHC and dont react to self antigens