Lecture 23: Anatomy and Physiology II (blood/cardiovascular) Flashcards
What does the body contain and what are they called?
Red blood cells that are called erythrocytes
What is the shape of RBC?
Biconcave disk that increases surface area for gas exchange, places cell membrane closer to hemoglobin. Also, as they mature, they lose their nuclei for more oxygen as well as mitochondria
What happens when RBC lose their nucleus?
There is no DNA and they cannot produce cell division or protein synthesis.
What happens when RBC lose their mitochondria?
They cannot perform cellular respiration and instead only glycolysis and do not use the oxygen that they carry
What are hemoglobins?
Protein complexes that bind to oxygen
What is heme?
The red pigment that contains iron and binds to oxygem
What is globin?
A 4 part protein complex that binds to carbon dioxide
What gives RBC their red color?
hemoglobin
What is oxyhemoglobin?
It is when hemoglobin binds to oxygen and this is bright red in color
What is deoxyhemoglobin?
It is when hemoglobin does not bind to oxygen and instead is a dark red color. An example are veins where they appear blue and filters the red color
Where are new red blood cells made?
Red bone marrow in adults and this is known as erythriopoiesis
Where are RBC produced from?
Hematopoietic stem cells that are triggered by erythripoeitin by the kidneys and liver in response to oxygen deficiency
What is needed to make more RBC?
Dietary needs like B-complex like B12 and folic acid for DNA synthesis. Also, iron for hemoglobin synthesis.
What is the first step in RBC destruction?
- they circulate in the body for 120 days
- macrophage destroy the RBC and this occurs in the liver and spleen
What happens after the macrophage destroy the RBC? Second step.
- The hemoglobin is broken down into amino acids and iron to be recycled
What happens when the amino acid is broken down and recycled? Third step.
Heme decomposes into biliverdin (green) and bilirubin(yellow) pigment and is released as bile pigments
What is the last step in RBC destruction?
Degraded pigment leaves as stercobilin(brown) and urobilin(yellow)
What is the epicardium?
It is the outer layer and it means “on the heart”. It is also a part of the pericardial to protect the heart from friction.
What is the myocardium?
It is the cardiac muscle and it is the middle layer that means the “muscle heart”