lecture 19 Flashcards
what are the two forms oxygen is carried in the blood?
bound to haemoglobin
dissolved O2
How much blood is dissolved in a litre of blood?
3mL of O2
Binding of oxygen depends on?
Pressure of O2
Right shift in curve can be caused by?
increased temperature
increases PCO2
Reduced pH - Bohr’s effect
Left shift in curve caused by?
Increased pH
reduced temperature
Decreased PCO2
What causes reduced O2 affinity?
higher temperature
lower plasma pH
What are the 3 forms CO2 is transported in?
Dissolved in plasma (7%)
Bicarbonate (70%)
Combined with proteins (23%)
What other product is formed with bicarbonate?
H+ ions -> decrease in pH
Why do we need to maintain normal levels of O2 and CO2?
metabolic and biochemical stability
What is the central controller of breathing?
Pons
medulla
other parts if the brain
What are the effectors of the breathing?
Muscles of respiration
What are the sensors of breathing?
chemoreceptors
baroreceptors
lung stretch receptors
protective reflexes
What is the role of the higher centres of respiratory controls?
Can alter the activity of the pneumotaxic centres
What is the role apneustic and pneumotaxic centres in the pons?
Adjust the output of the respiratory rhythmicity centres
What is the role of the respiratory rhythmiticity centres?
Generate cycles of contraction and relaxation in the diaphragm establishing pace off respiration