L17. Innate Immunity Flashcards
Innate immunity is non specific, but adaptive immunity is ____________________
Specific and acquired
Does innate immunity have memory or lasting immunity?
No
Name the 3 levels of innate immunity.
- Epithelium (physical barrier)
- Innate cell subsets (marcophages, neutrophils, antigen presenting dendritic cells)
- Chemokines and cytokines
- Name the 4 main families of the epithelium’s anti-microbial peptides.
- B-defensins
- Human neutrophil peptides
- Cathelicidens
- Psoriasin proteins
Where is secretory IgA produced?
Mucosal surfaces. It binds to flagella to inhibit bacteria movement
- What is lactoferrin?
A glycoprotein that transports iron ions with antimicrobial activity.
*Where is lactoferrin present?
In saliva
*What cell type produced Lactoferrin?
Neutrophils
*What does lysozyme do?
It targets bacterial cell walls
*Where is lysozyme present?
In saliva
*Which cells produce lysozyme?
Macrophages and neutrophils
*What do cystatins do?
Have anti-protease activity and supports tooth remineralisation
What do toll like receptors do?
Recognise bacterial and viral antigens
Give 2 examples of toll-like receptors
TLR-2
TLR-4
What do cytokines do?
They instruct a cell what to do. They are signalling molecules to co-ordinate immune responses
What 3 types of cytokines are there?
Autocrine - self-regulating
Paracrine - alters the behaviour of neighbouring cells
Endocrine - alters the behaviour of distant cells
What is the role of chemokines?
Chemotaxis. They tell cells where to go.
What kind of proteins are chemokines?
Signalling proteins
What does AMP stand for?
Anti-microbial peptides
