L17. Innate Immunity Flashcards
Innate immunity is non specific, but adaptive immunity is ____________________
Specific and acquired
Does innate immunity have memory or lasting immunity?
No
Name the 3 levels of innate immunity.
- Epithelium (physical barrier)
- Innate cell subsets (marcophages, neutrophils, antigen presenting dendritic cells)
- Chemokines and cytokines
- Name the 4 main families of the epithelium’s anti-microbial peptides.
- B-defensins
- Human neutrophil peptides
- Cathelicidens
- Psoriasin proteins
Where is secretory IgA produced?
Mucosal surfaces. It binds to flagella to inhibit bacteria movement
- What is lactoferrin?
A glycoprotein that transports iron ions with antimicrobial activity.
*Where is lactoferrin present?
In saliva
*What cell type produced Lactoferrin?
Neutrophils
*What does lysozyme do?
It targets bacterial cell walls
*Where is lysozyme present?
In saliva
*Which cells produce lysozyme?
Macrophages and neutrophils
*What do cystatins do?
Have anti-protease activity and supports tooth remineralisation
What do toll like receptors do?
Recognise bacterial and viral antigens
Give 2 examples of toll-like receptors
TLR-2
TLR-4
What do cytokines do?
They instruct a cell what to do. They are signalling molecules to co-ordinate immune responses
