INTRO TO PHARMACOLOGY Flashcards

1
Q

what is pharmacology?

A

actions, mechanisms, uses and adverse effects of drugs

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2
Q

what is a drug?

A

any natural or synthetic substance which alters the state of a living organisms

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3
Q

what classes of drugs are there?

A

medicinal or non-medicinal

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4
Q

define pharmacodynamics

A

what the drug does to the body (how it acts, what side effects it may produce)

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5
Q

define pharmacokinetics

A

what the body does to the drug (how it gets into and out of the body)

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6
Q

how are drugs discovered?

A

natural sources: plants, animals, minerals
understanding neurotransmitters and hormones
improving naturally occurring drugs

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7
Q

where do ideas for new drugs come from?

A

understanding mediators of disease

understanding enzymes, substrates, products

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8
Q

how are drugs names?

A

generic, brand or proprietary

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9
Q

how are drugs classified?

A

molecular action
chemical structure
pharmacotherapeutic action
BNF

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10
Q

how so drugs work on a cellular level?

A

On transport systems of membranes
On enzymes
On receptors

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11
Q

what are type 1 receptors?

A

ionotropic: receptor linked to ion channel

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12
Q

what are type 2 receptors?

A

metabotropic: G-protein-linked receptors

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13
Q

what are type 3 receptors?

A

tyrosine kinase linked receptors

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14
Q

what are type 4 receptors?

A

DNA-linked receptors/intracellular receptors

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15
Q

what does compliance mean?

A

is the patient taking the drug as directed?

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16
Q

how are drugs tested in humans?

A
Clinical trials
Phase 1 - volunteers
Phase2 – few patients
Phase 3 – many patients
Licenced for use by MHRA
Phase 4 – post-licence surveillance & trials
17
Q

what are possible benefits of taking a drug?

A

Allieviate symptoms cure diseases
modify course of disease
prevent diseases
aid to procedures lifestyle aids

18
Q

what are +ve/-ve characteristics of a drug?

A

Specificity, potency, duration of action, ease of use, side effects, toxicity, teratogenicity, cost, availability