EPITHELIAL TISSUE Flashcards
what are the 3 primitive (germ cell) layers?
Mesoderm / Ectoderm / Endoderm
what is connective tissue derived from?
mesoderm
what is muscular tissue derived from?
mesoderm
what is nervous tissue derived from?
ectoderm
what is epithelium tissue derived from?
meso, ecto and endoderm
what is epithelia?
tissues that serve as protective layers and/or secretory components of body organs and systems
what is the characteristics of epithelia?
Formed into tightly cohesive cellular sheets
what is the function of epithelia?
Function is to cover/line body surfaces
e.g. Alimentary canal, Exocrine ducts
what does epithelia form?
functional unit of secretory glands e.g. Salivary, Mammary, Sweat
what are common attributes of epithelia?
Limited intercellular space Single/multiple layers of cells Free apical surfaces Basement membrane Mitotic capability
why does epithelia have limited intracellular space?
Specialised intercellular junctions hold cell memb close together - effective barrier - blocks infiltration of fluids between cells
why does epithelia have single/multiple layers?
Form linings/coverings. where diffusion/filtration is important, epithelia is single layer
where protection e.g. abrasion is needed - multiple layers
what is the free apical surface?
formed during development or at maturity. The apical surface is where cells of an epithelium face internal lumens
what is the basement memb?
opposite to the apical surface. Basal surface attaches to underlying tissues via basement memb derived from underlying CT.
why does epithelia have mitotic capability?
Epithelia covering/lining tissues are constantly subjected to wear and tear. This enables repair and regeneration.
what are epithelia’s distinguishing features?
All the vital traffic of the body passes through epithelial layer. e.g. digested food, oxygen, secretions
High capacity for regeneration.e.g. wound healing, intestinal abrasion
what are the different arrangements of cells in epithelia?
Simple, Pseudostratified, Stratified
what are the different cell shapes in epithelia?
Squamous , Cuboidal, Columnar, Transitional
what is simple epithelia?
one cell thick
what is stratified epithelia?
many cells thick but only bottom layer in contact with basement memb
what is pseudostratified epithelia?
appear more than one cell thick but all cells rest on basement memb
what do squamous cell look like?
flattened cells like paving stones
what do columnar cells look like?
cells are taller than they are wide
what do cuboidal cells look like?
cells are of similar height depth and width
what do transitional cells look like?
cells in layers which change their shape when they are stretched
where is simple squamous found?
alveoli & capillaries of lungs
where is simple cubical found?
kidney tubule
where is simple columnar found?
small intestine
where is transitional epithelia found?
only in urinary tract
stretches to accommodate fluid changes
where is stratified squamous found?
oesophagus
where is keratinised stratified squamous found?
only found in skin
where is pseudostratfied epithelia found?
trachea, nasal mucosa
where is stratified cuboidal found?
sweat gland duct
where is stratified columnar found?
salivary gland duct
why is the epithelial surface subject to modifications?
Due to wide variety of functions – plasma memb often specialised to enhance functions+maintain cellular integrity
what are the modifications of the epithelial surface?
Free luminal surface
Basal fixed surface
Lateral surface
what is the basement membrane?
Separation from the underlying CT
what is the function of the basement membrane?
acts to support epithelia a selectively permeable filter between epithelium and CT
what is the basal lamina?
supportive sheet between epithelium and underlying CT
what does the basement membrane consist of?
basal lamina plus underlying reticular fibre layer
what is the microvilli?
Finger-like extensions of the plasma memb of apical epithelial cell
what is the function of the microvilli and where is it found?
Increase surface area for absorption
e.g. Small Intestine
what is the cilia?
Whip-like, motile extensions
what is the function of the cilia and where is it found?
Moves mucus over epithelial surface, in one direction e.g. Trachea and Resp Bronchus
what are desmosomes?
adhesive spots on lateral sides
involves proteins called cadherins
where are tight junctions found?
at apical area
what are tight junctions?
plasma memb of adjacent cells fuse,
nothing passes
give an example of where tight junctions are found
GI tract, doesn’t let enzymes from gut into blood stream
what are gap junctions?
spot-like junction occurring anywhere
lets small molecules pass
what is the glandular epithelium?
aggregates of epithelial cells clustered together to perform specific secretory/excretory function
what do glandular epithelium secrete?
hormones, enzymes, milk, sweat, mucous,oil
what is an exocrine gland?
pour products into ducts that open into lumen of organ or onto the skin
what is an endocrine gland?
ductless glands – secrete into empty tissues spaces – eventually enter blood stream
what is a merocrine gland?
e.g. salivary gland - secretion passes from cells without damage to plasma membrane – exocytosis
what is a holocrine gland?
e.g. sebaceous gland –cellular debris part of secretion (sebum)
involves death of the cell
what is an apocrine gland?
e.g. mammary gland –
apical end pinched off
how do most glands secrete products?
merocrine
what is a simple gland?
single tube
what is a compound gland?
branched duct system
what is a secretory gland?
Tubular, Acinar/Alveolar, Saccular (pouch like)
what is an epithelial membrane?
Thin sheets of flexible tissue that line or cover parts of the body
what does an epithelial membrane contain?
contain epithelium and an underlying CT (mucous, serous, cutaneous memb)
what are synovial membranes?
contain only CT, and line the cavities of synovial joints
what are serous membranes?
simple squamous
resting on thin layer loose CT
where are serous membranes found?
line closed body cavities
serous fluid – lubrication
what are mucous membranes?
lines cavities open to outside
where are mucous membranes found?
mucus cells/glands lumen of digestive (microvilli), reproductive, resp tracts (ciliated)
what are cutaneous membranes?
skin
stratified squamous epithelium
where are synovial membranes found?
joints synovial fluid
epithelial layer incomplete
what is the function of serous membranes?
cover the surface of organs that are not exposed to the outside & secrete a watery fluid
what are the 2 layers of serous membrane?
parietal and visceral
what is the parietal layer?
attaches to the body wall around the organ
what is the visceral layer?
attaches to the organs themselves
what does cutaneous membranes line?
skin, covering the outer surface of the body
what does synovial membranes line?
cavities of freely movable joints, and contain only CT
what do basal cell carcinoma (BCC) show?
nodular masses of basaloid cells
what do squamous cell carcinoma (SCC) show?
irregular masses of atypical epidermal keratinocyte tumour masses