Innate Immunity

Question 1

What are the 3 phases of immunity?

Answer 1

+ innate
+ early induced
+ adaptive

Question 2

What are the three activation pathways of the complementary system?

Answer 2

+ classical
+ lectin
+ alternative

Question 3

What is the trigger for the classical pathway?

Answer 3

antibody binds to specific antigen on pathogen surface

Question 4

What is the trigger for the lectin pathway?

Answer 4

mannose-binding protein binds to pathogen surface

Question 5

What is the trigger for the alternative pathway?

Answer 5

pathogen surface creates local environment conducive to complement activation

Question 6

What is the output for the classical pathway?

Answer 6

recruitment of inflammatory cells

Question 7

What is the output for the lectin pathway?

Answer 7

opsonisation of pathogens, facilitating uptake and killing by phagocytic cells

Question 8

What is the output for the alternative pathway?

Answer 8

lysis and death of pathogens

Question 9

What is the role of complement protein, C3b?

Answer 9

opsonin - promotes phagocytosis

Question 10

What is the role of the complement protein, C3a?

Answer 10

peptide mediator for inflammation