Bone Growth and Fractures Flashcards
what is the role of sex steroids in bone growth?
stimulate bone growth spurt but promote close of epiphyseal plates
what happens to bone growth at end of puberty?
- growth in length ceases
- cell proliferation slows and plate thins
- plate invaded by blood vessels
- epiphyseal and diaphyseal vessels unite
- may leave visible line on x-rays
which bones have only one ossification centre?
- carpals
- tarsals
- ear ossicles
which bones have 2+ ossification centres?
head of humerus has 3
what are the zones of the epiphyseal plate?
- ossification (osteogenic)
- calcification
- hypertrophic
- growth (proliferation)
- resting zone
what is the function of the resting zone?
matrix production
what is the function of the growth zone?
cell proliferation
what is the function of the hypertrophic zone?
calcification of matrix
what is the function of the metaphysis zone?
- bone formation
- vascularisation
what are examples of diseases due to defects in resting zone?
diastrophic dwarfism:
- defective collagen synthesis/processing of proteoglycans
what are examples of diseases due to defects in growth zone?
achondroplasia; malnutrition; irradiation injury:
- deficiency in cell proliferation and/or matrix synthesis
gigantism:
- increased cell proliferation
what are examples of diseases due to defects in hypertrophic zone?
rickets; osteomalacia:
- insufficiency of calcium or phosphate for normal calcification
what are examples of diseases due to defects in metaphysis zone?
osteomyelitis:
- bacterial infection
osteogenesis imperfecta:
- abnormality
scurvy:
- inadequate collagen turnover
what are the requirements of normal growth and bone development?
- calcium
- phosphorus
- vitamin A, C, D
- balance between growth hormone, thyroid/parathyroid, oestrogen/androgens
what is the ratio of cortical/compact bone to cancellous/trabecular bone?
8:2
what is the location of cortical/compact bone?
shaft of long bones
what is the location of cancellous/trabecular bone?
- ends of long bones
- vertical bodies
- flat bones
what is the structure of cortical/compact bone?
concentrically arranged lamellae - haversian systems