Atherosclerosis Flashcards

1
Q

What are causes of chronic endothelial injury/dysfunction?

A
\+ haemodynamic disturbances
\+ hypercholesterolemia
\+ hypertension
\+ smoking 
\+ toxins
\+ viruses
\+ immune reactions
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what are examples of endothelial dysfunction?

A

+ increased endothelial permeability
+ increased leukocyte adhesion
+ increased monocyte adhesion and migration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what are the effects of hyperlipidaemia (LDL cholesterol)?

A

+ impairs endothelial function
+ accumulates within intima
+ causes oxidative modification of LDL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what is the role of macrophages in endothelial injury?

A

+ engulf oxidised LDL (foam cells)

+ secrete IL1, TNF, MCP1 and growth factors

+ causes fatty streaks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what is the role of smooth muscle proliferation in endothelial injury?

A

+ collagen and extracellular matrix deposition

+ turns fatty streaks into mature fibro-fatty atheromas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly