Drug-Receptor Interactions 1 and 2

Question 1

what 4 regulatory protein families are commonly drug targets and covered by term “receptor”?

Answer 1

1. enzymes
2. carrier molecules (transporters)
3. ion channels
4. NTs, hormones or local hormone receptors

Question 2

how can partial agonists affect response to full agonist?

Answer 2

can decrease response to full agonist as some receptors will be occupied by partial receptors, giving a smaller response than if all receptors were occupied by full agonists

Question 3

what is a competitive antagonist?

Answer 3

a drug which interacts/binds REVERSIBLY with receptors to form a complex but DOES NOT evoke a response

Question 4

what is drug affinity?

Answer 4

(KD or KA) - measure of concentration range over which a drug binds to its receptor

Question 5

what is efficacy?

Answer 5

ability of drug to generate/initiate a stimulus once bound to its receptor