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Microbiology > Immunoglobulin Classes (Isotypes) > Flashcards

Immunoglobulin Classes (Isotypes) Flashcards

1
Q

What are the 5 immunoglobulin classes?

A

IgM, IgG, IgA, IgD, IgE

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2
Q

which antibody is the largest?

A

IgM pentamer

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3
Q

which is the first antibody class produced?

A

IgM

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4
Q

IgM is produced in response to what?

A

T-independent antigens

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5
Q

which antibody class is produced in response to T-independent antigens

A

IgM

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6
Q

which antibody class is produced in blood only, not tissues

A

IgM

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7
Q

IgM is found in _____ only, not in _____

A

blood, tissues

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8
Q

complement activation is most efficient in which antibody class?

A

IgM

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9
Q

what innate immune response is most efficient when it comes to IgM?

A

complement activation

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10
Q

name three protective outcomes of IgM binding?

A

neutralization, immobilization, cross-linking

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11
Q

neutralization, immobilization, cross-linking are characteristic of which antibody class?

A

IgM

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12
Q

which antibody class has a long half life (21 days)

A

IgG

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13
Q

which antibody class is found in blood and tissues?

A

IgG

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14
Q

IgG is found in….

A

blood and tissues

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15
Q

which antibody class crosses the placenta? why?

A

IgG. protect fetus.

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16
Q

IgG crosses the… in order to…

A

placenta to protect the fetus

17
Q

which antibody class is involved in all types of protective outcomes including ADCC?

18
Q

which protective outcomes is IgG involved in?

A

all of them, including ADCC

19
Q

monomer or dimer is secreted, very little dimer in serum, serum has monomer

20
Q

connect IgA, monomer, dimer, serum

A

monomer or dimer is secreted, very little dimer in serum, serum has monomer

21
Q

where is IgA found?

A

mucous, tears, saliva, brst milk

22
Q

which antibody class is found in tears, saliva, brst milk, mucous

23
Q

which antibody class is produced by plasma cells of MALT

24
Q

IgA is produced by…

A

plasma cells of MALT

25
Q

which antibody class is the most important?

26
Q

what type of protection does IgA provide?

A

mucosal protection, protects all mucosal-lined tracts

27
Q

protection of mucosal-lined tracts is provided by which antibody class?

28
Q

which antibody class did we learn nothing about?

29
Q

which antibody class is bound by Fc portion to mast cells and basphils

30
Q

IgE is bound by…

A

Fc portion to mast cells and basphils

31
Q

crosslink antigens on basophils and mast cells causing them to release histamine

32
Q

relate IgE to histamine release

A

crosslink antigens on basophils and mast cells causing them to release histamine

33
Q

which antibody class’ primary role is an anti-parasitic function?

34
Q

primary role of IgE?

A

anti-parasitic function

35
Q

which antibody class is responsible for allergic reactions?

36
Q

IgE is responsible for….

A

allergic reactions

Microbiology (45 decks)

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