Immunoglobulin Classes (Isotypes)

Question 1

What are the 5 immunoglobulin classes?

Answer 1

IgM, IgG, IgA, IgD, IgE

Question 2

which antibody is the largest?

Answer 2

IgM pentamer

Question 3

which is the first antibody class produced?

Answer 3

IgM

Question 4

IgM is produced in response to what?

Answer 4

T-independent antigens

Question 5

which antibody class is produced in response to T-independent antigens

Answer 5

IgM

Question 6

which antibody class is produced in blood only, not tissues

Answer 6

IgM

Question 7

IgM is found in _____ only, not in _____

Answer 7

blood, tissues

Question 8

complement activation is most efficient in which antibody class?

Answer 8

IgM

Question 9

what innate immune response is most efficient when it comes to IgM?

Answer 9

complement activation

Question 10

name three protective outcomes of IgM binding?

Answer 10

neutralization, immobilization, cross-linking

Question 11

neutralization, immobilization, cross-linking are characteristic of which antibody class?

Answer 11

IgM

Question 12

which antibody class has a long half life (21 days)

Answer 12

IgG

Question 13

which antibody class is found in blood and tissues?

Answer 13

IgG

Question 14

IgG is found in….

Answer 14

blood and tissues

Question 15

which antibody class crosses the placenta? why?

Answer 15

IgG. protect fetus.

Question 16

IgG crosses the… in order to…

Answer 16

placenta to protect the fetus

Question 17

which antibody class is involved in all types of protective outcomes including ADCC?

Answer 17

IgG

Question 18

which protective outcomes is IgG involved in?

Answer 18

all of them, including ADCC

Question 19

monomer or dimer is secreted, very little dimer in serum, serum has monomer

Answer 19

IgA

Question 20

connect IgA, monomer, dimer, serum

Answer 20

monomer or dimer is secreted, very little dimer in serum, serum has monomer

Question 21

where is IgA found?

Answer 21

mucous, tears, saliva, brst milk

Question 22

which antibody class is found in tears, saliva, brst milk, mucous

Answer 22

IgA

Question 23

which antibody class is produced by plasma cells of MALT

Answer 23

IgA

Question 24

IgA is produced by…

Answer 24

plasma cells of MALT

Question 25

which antibody class is the most important?

Answer 25

IgG

Question 26

what type of protection does IgA provide?

Answer 26

mucosal protection, protects all mucosal-lined tracts

Question 27

protection of mucosal-lined tracts is provided by which antibody class?

Answer 27

IgA

Question 28

which antibody class did we learn nothing about?

Answer 28

IgD

Question 29

which antibody class is bound by Fc portion to mast cells and basphils

Answer 29

IgE

Question 30

IgE is bound by…

Answer 30

Fc portion to mast cells and basphils

Question 31

crosslink antigens on basophils and mast cells causing them to release histamine

Answer 31

IgE

Question 32

relate IgE to histamine release

Answer 32

crosslink antigens on basophils and mast cells causing them to release histamine

Question 33

which antibody class’ primary role is an anti-parasitic function?

Answer 33

IgE

Question 34

primary role of IgE?

Answer 34

anti-parasitic function

Question 35

which antibody class is responsible for allergic reactions?

Answer 35

IgE

Question 36

IgE is responsible for….

Answer 36

allergic reactions