10.17.2022. IS questions

Question 1

Compare and contrast the B cell receptor and T cell receptor. Know similarities and differences

Answer 1

similarities: antigen-binding site to bind/recognize antigens
differences: T cells only bind an antigen that is presented by one of our own body cells. B cells have two antigen-binding sites, and bind free antigens, aka antigens not presented by our body’s own cells

Question 2

Does a T cell receptor bind a free antigen?

Answer 2

NO!

Question 3

Does a B cell receptor bind a free antigen?

Answer 3

YES!

Question 4

What kind of antigens does a T cell bind?

Answer 4

only bind an antigen presented by the body’s own cell

Question 5

What two molecules present antigens to T cells?

Question 6

Which MHC molecule presents exogenous antigens?

Answer 6

MHC II

Question 7

Which MHC molecule presents endogenous antigens?

Answer 7

MHC I

Question 8

Which antigen-presenting molecule does a TH cell recognize?

Answer 8

MHC II

Question 9

Which antigen-presenting molecule does a Tc cell recognize?

Answer 9

MHC I

Question 10

Which T cells have CH4, and which have CD8?

Answer 10

CD4: Th
CD8: Tc

Question 11

Describe the role of Th cells in B cell activation

Answer 11

for a B cell to be activated, two things must happen:
1. it must bind an epitope
2. Th cell must activate it.
if a Th cell recognizes the antigen fragment, the B cell is activated to go fight infection. if the antigen fragment is not recognized by the Th cell, there is nothing to fight, the B cell becomes anergic –> apoptosis