Idek man Flashcards

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1
Q

what type of cells make up our mucous membranes?

A

columnar epithelium cells

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2
Q

how can the mucosal membrane barrier be compromised? (3 broad groups and one example of each)

A
  1. Respiratory Tract (smoking, respiratory infections, cold temp and low moisture)
  2. Digestive tract (ulcers/wounds/breaks, constipation, acid reflux)
  3. Reproductive tract (intercourse, ulcers, lesions via STDs)
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3
Q

what two sentinel cells should we know for class? what’s a broader name for sentinel cells and what immune system are they a part of?

A

macrophages, dendritic cells. phagocytes, innate immune system.

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4
Q

what three ways do sensory cells communicate?

A

cytokines (voice)
surface receptors (eyes, ears)
adhesion molecules (hands)

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5
Q

what is the language used by the immune system?

A

cytokines

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6
Q

what are cytokines?

A

small, soluble proteins which bind to receptors on other cells and signal the transcription and translation events within that cell

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7
Q

why would we want to know what cytokines do, i.e. what changes they make?

A

to use them therapeutically

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8
Q

what cytokines are used in cell communication (for this class’ purposes)?

A

chemokines
interferons
interleukins (ILs)
Tumor Necrosis Factor

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9
Q

TNF = ? what kind of cell is it?

A

tumor necrosis factor, cytokine

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10
Q

ILs = ? what kind of cells are they?

A

interleukins

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11
Q

name the anti inflammatory cytokines. name them now!

A

IL-10

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12
Q

name the pro inflammatory cytokines. name them now!

A

IL1, IL6, TNF

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13
Q

pro inflammatory or anti inflammatory: IL 10

A

anti

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14
Q

pro inflammatory or anti inflammatory: IL 1

A

pro

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15
Q

pro inflammatory or anti inflammatory: IL 6

A

pro

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16
Q

pro inflammatory or anti inflammatory: TNF

A

pro

17
Q

name cytoplasmic PRRs

A

NLR, RLR

18
Q

name surface/membrane PRRs

A

TLR

19
Q

what may be responsible for inflammatory diseases like Crohn’s

A

mutations in NLRs

20
Q

?? NLR detects… (2)

A

?? flagellin, compounds that indicate cell damage

21
Q

RLR detects… (2)

A

dsRNA, uncapped ssRNA

22
Q

?? NLR detects…

A

?? peptidoglycan

23
Q

downstream effect of NOD is….

A

inflammatory response

24
Q

downstream effect of RIG is…

A

interferon response

25
Q

what PRR led to an inflammatory response?

A

NOD

26
Q

what PRR led to an interferon response?

A

RIG